Pegylated interferon and ribavirin-induced interstitial pneumonitis with ARDS
Pegylated interferon and ribavirin-induced interstitial pneumonitis with ARDS
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DOI：
10.1378/chest.124.1.406
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发表时间：
2003-07-01
期刊：
影响因子：
9.6
通讯作者：
Hallisey, RK
中科院分区：
文献类型：
--
作者：
Abi-Nassif, S;Mark, EJ;Hallisey, RK
一名因丙型肝炎病毒导致肝硬化的49岁男性患者，在两周剂量的聚乙二醇化干扰素- α (2)b联合利巴韦林后，通过外科肺活检标本评估，出现了间质性肺炎。他发展为急性呼吸窘迫综合征，住院26天后死于多系统器官衰竭。本病例提示聚乙二醇化干扰素- α (2)b治疗可发生间质性肺疾病。
A 49-year-old man with cirrhosis due to hepatitis C virus developed interstitial pneumonitis documented by surgical lung biopsy specimen evaluation after two weekly doses of pegylated interferon-alpha(2)b in combination with ribavirin. He developed ARDS and died after 26 days of hospitalization from multisystem organ failure. This case suggests that interstitial pulmonary disease can occur with pegylated interferon-alpha(2)b therapy.