PDZ Binding Kinase/T-LAK Cell-Derived Protein Kinase Plays an Oncogenic Role and Promotes Immune Escape in Human Tumors.
PDZ Binding Kinase/T-LAK Cell-Derived Protein Kinase Plays an Oncogenic Role and Promotes Immune Escape in Human Tumors.
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DOI：
10.1155/2021/8892479
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发表时间：
2021
影响因子：
--
通讯作者：
Su D
中科院分区：
文献类型：
--
作者：
Feng T;Zhang Y;Ling S;Xu C;Lyu Y;Lu T;Liu X;Ying L;Wan Y;Zhong H;Su D
PDZ结合激酶(PBK)/T-LAK细胞衍生蛋白激酶(TOPK)是一种重要的有丝分裂激酶，在某些肿瘤中促进肿瘤的发展。然而，PBK/TOPK的泛癌分析及其在肿瘤免疫中的作用是有限的。使用多种数据库，包括Oncomine、人类蛋白质图谱、Ulcan、肿瘤免疫估计资源2.0、字符串和基因表达谱交互分析2，以及从癌症基因组图谱和基因-组织表达项目收集的数据，探索了PBK在各种癌症中的致癌和免疫作用。几种生物信息学工具和方法被用于定量分析和全景描述，如DESeq2和肿瘤免疫功能障碍和排斥(TID)算法。在多个数据库中，PBK在大多数实体瘤中的表达水平高于在正常组织中的表达。在大多数病例中，PBK与肿瘤的分期、分级和预后不良有关。PBK在大多数病例中与肿瘤免疫细胞浸润有关，尤其与KIRC、LGG和LIHC中的TAMS、Tregs、MDSCs和T细胞耗竭呈正相关。PBK在多种肿瘤中与TMB、MSI和免疫检查点基因密切相关，在KIRC、LGG和LIHC中PBK高表达的患者在预测结果中有更高的潮汐评分和更低的免疫应答。根据GO和KEGG富集度分析，PBK与LIHC和LGG的细胞周期调节和免疫相关过程密切相关。PBK可能在大多数实体肿瘤中发挥致癌作用，并促进免疫逃逸，特别是在KIRC、LGG和LIHC中。本研究提示PBK抑制剂联合免疫治疗的潜在价值。
PDZ binding kinase (PBK)/T-LAK cell-derived protein kinase (TOPK) is an important mitotic kinase that promotes tumor progression in some cancers. However, the pan-cancer analysis of PBK/TOPK and its role in tumor immunity are limited. The oncogenic and immune roles of PBK in various cancers were explored using multiple databases, including Oncomine, Human Protein Atlas, ULCAN, Tumor Immune Estimation Resource 2.0, STRING, and Gene Expression Profiling Interactive Analysis 2, and data collected from The Cancer Genome Atlas and Genotype-Tissue Expression Project. Several bioinformatics tools and methods were used for quantitative analyses and panoramic descriptions, such as the DESeq2 and Tumor Immune Dysfunction and Exclusion (TIDE) algorithm. PBK was expressed at higher levels in most solid tumors than in normal tissues in multiple databases. PBK was associated with an advanced tumor stage and grade and a poor prognosis in most cases. PBK was associated with tumor immune cell infiltration in most cases and was especially positively correlated with TAMs, Tregs, MDSCs, and T cell exhaustion in KIRC, LGG, and LIHC. PBK was closely related to TMB, MSI, and immune checkpoint genes in various cancers, and patients with higher expression of PBK in KIRC, LGG, and LIHC had higher TIDE scores and lower immune responses in the predicted results. PBK was closely related to cell cycle regulation and immune-related processes in LIHC and LGG according to GO and KEGG enrichment analyses. PBK may play an oncogenic role in most solid tumors and promotes immune escape, especially in KIRC, LGG, and LIHC. This study suggests the potential value of PBK inhibitors combined with immunotherapy.
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影响因子：
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作者：
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