Atrophic and regenerative changes in rabbit mimic muscles after lidocaine and bupivacaine application
Atrophic and regenerative changes in rabbit mimic muscles after lidocaine and bupivacaine application
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DOI：
10.1046/j.1439-0264.2003.00439.x
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发表时间：
2003-02-01
期刊：
影响因子：
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通讯作者：
Sabuncuoglu, H
中科院分区：
文献类型：
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作者：
Çalgüner, E;Gözil, R;Sabuncuoglu, H
通过在家兔面神经周围注射利多卡因或布比卡因引起面神经麻痹，观察局部麻醉剂对骨骼肌的破坏和去神经萎缩。然后在注射后2、4、6和8周处死动物，通过光镜和电镜观察模拟肌肉组织在每个阶段的变化。注射后2-6周观察到萎缩变化，6-8周开始再生。与布比卡因相比，利多卡因引起更剧烈的萎缩变化，并与较慢的肌肉再生有关。
Destruction and denervation atrophy in skeletal muscles caused by the injection of local anaesthetics was investigated by injecting lidocaine or bupivacaine around the rabbit facial nerve to produce facial paralysis. Animals were then sacrificed at 2, 4, 6, and 8 weeks post-injection, and changes in mimic muscle tissue were assessed at each stage by light microscopy and electron microscopy. Atrophic changes were observed at 2-6 weeks after injection, and regeneration started at 6-8 weeks. Compared to bupivacaine, lidocaine caused more dramatic atrophic changes and was associated with slower muscle regeneration.