Pulmonary arterial and venous pressures measured with small catheters in dogs.
Pulmonary arterial and venous pressures measured with small catheters in dogs.
复制标题
用小导管测量狗的肺动脉压和静脉压。
DOI：
10.1152/jappl.1984.57.2.309
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
H. Chang
中科院分区：
文献类型：
--
作者：
R. Michel;T. Hakim;H. Chang
为了进一步细分从闭塞技术获得的动脉段、中段和静脉段上的压降，我们比较了用该技术测量的动脉段远端（Pa '）和静脉段近端（Pv'）处的压力，用1.2-mm导管在原位灌注的狗的左下叶的小动脉（Psa）和小静脉（Psv）中测量压力。监测动脉压（Pa）和静脉压（Pv），并保持血流恒定。在对照条件下，平均Pa、Psa、Pa '、Pv'、Psv和Pv分别为18.1、13.0、11.3、9.2、8.4和0.7 mmHg，表明29%和44%的总肺血管阻力（PVR）在直径大于1.2 mm的动脉和静脉中。血清素和组胺分别增加动脉和静脉中的压降，大于和小于1.2 mm。小导管压力随流速增加。根据闭塞和小导管测量值计算的微血管压力高于根据假设静脉侧PVR为40%的公式计算的微血管压力。我们的数据表明，肺中相当大比例的阻力可能存在于较大的动脉和静脉中，血管收缩剂可增加1.2 mm以下血管中的阻力分数，动脉和静脉段包括1.2 mm以下的肌肉血管，假设静脉中阻力为40%的微血管压力计算可能会产生误导，尤其是当血管张力增加时。
To further subdivide the pressure drops across the arterial, middle, and venous segments obtained from the occlusion technique, we compared the pressures at the distal end of the arterial segment (Pa') and the proximal end of the venous segment (Pv') measured with this technique, with the pressures measured with 1.2-mm catheters in a small artery (Psa) and a small vein (Psv) of left lower lobes of dogs perfused in situ. The arterial (Pa) and venous (Pv) pressures were monitored and blood flow kept constant. Under control conditions the mean Pa, Psa, Pa', Pv', Psv, and Pv were 18.1, 13.0, 11.3, 9.2, 8.4, and 0.7 mmHg, respectively, suggesting that 29 and 44% of the total pulmonary vascular resistance (PVR) were in arteries and veins with diameters larger than at least 1.2 mm. Serotonin and histamine increased the pressure drops in arteries and veins, respectively, both larger and smaller than 1.2 mm. The small catheter pressures increased with flow rate. Microvascular pressures calculated from occlusion and small catheter measurements were higher than those calculated from the formula assuming 40% of PVR on the venous side. Our data suggest that a substantial proportion of resistance in the lung may lie in larger arteries and veins, the fraction of resistance in vessels under 1.2 mm increases with vasoconstrictors, the arterial and venous segments include muscular vessels under 1.2 mm, and calculation of microvascular pressures assuming 40% of the resistance in the veins may be misleading, especially when vasomotor tone is increased.