INHIBITION OF HUMAN IMMUNODEFICIENCY VIRAL REPLICATION BY TANNINS AND RELATED-COMPOUNDS
INHIBITION OF HUMAN IMMUNODEFICIENCY VIRAL REPLICATION BY TANNINS AND RELATED-COMPOUNDS
复制标题
DOI：
10.1016/0166-3542(92)90008-s
复制
发表时间：
1992-05-01
影响因子：
7.6
通讯作者：
OKUDA, T
中科院分区：
文献类型：
--
作者：
NAKASHIMA, H;MURAKAMI, T;OKUDA, T
在87种化学定义的单宁及其相关化合物中，几种可水解单宁，而不是缩合单宁或其他低分子量多酚，在人淋巴细胞I型病毒（HTLV-1）阳性的MT-4细胞中显著抑制人类免疫缺陷病毒（HIV）的细胞病变作用和HIV抗原的表达。活性化合物的50%有效浓度（2.0 ~ 4.8 μ g/ml）比其50%细胞毒浓度低13 ~ 15倍。它们的抗HIV活性至少部分是通过抑制HIV对细胞的吸附而介导的。
Among 87 chemically defined tannins and related compounds, several hydrolyzable tannins, but not condensed tannins or other lower molecular weight polyphenols, significantly inhibited both the cytopathic effect of human immunodeficiency virus (HIV) and the expression of HIV antigen in human lymphotropic virus type I (HTLV-1)-positive MT-4 cells. The 50% effective concentrations (2.0-4.8-mu-g/ml) of the active compounds were 13- to 15-fold lower than their 50% cytotoxic concentrations. Their anti-HIV activity was demonstrated to be mediated, at least in part, by inhibition of HIV adsorption to the cells.