Night-time frequency of urination as a manifestation of sleep-disordered breathing: the Nagahama study
Night-time frequency of urination as a manifestation of sleep-disordered breathing: the Nagahama study
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DOI：
10.1016/j.sleep.2020.09.007
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发表时间：
2021-02-12
期刊：
影响因子：
4.8
通讯作者：
Chin, Kazuo
中科院分区：
文献类型：
--
作者：
Hamada, Satoshi;Tabara, Yasuharu;Chin, Kazuo
目的：睡眠呼吸障碍（SDB）是众所周知的心血管结局的危险因素。对SDB患者的研究已经确定夜间尿频是SDB的一种表现。我们的目的是澄清夜间排尿频率是否与一般人群中的SDB独立相关。我们还调查了夜间排尿频率是否可以帮助推定诊断SDB。方法：研究参与者包括7151名社区居民。使用脉搏血氧仪测量睡眠期间的氧饱和度，持续四个晚上。SDB定义为在活动描记法确定的睡眠期间，每小时氧饱和度下降超过或等于3%的事件≥ 15次。结果：夜间排尿次数与SDB呈显著正相关（无，5.8%; 1次/夜，14.1%; 2次/夜，20.1%; 3次/夜，28.7%; > 3次/夜，44.1%; P < 0.001）。这种关联与可能的协变量无关，包括睡眠时间（调整后的比值比：一次/晚= 1.50，两次/晚= 2.15，三次/晚= 3.07，>三次/晚= 3.73，P < 0.001）。与SDB显著相关的其他因素包括年龄、性别、肥胖、睡眠呼吸暂停和睡眠时间短。将夜间排尿频率作为SDB风险评分项目时，由这6个常规项目组成的SDB风险评分曲线下面积（0.834）显著提高（0.842，P = 0.001）。我们的研究结果表明，排尿频率应被认为是一种表现，SDB，即使在一般人群。(C)2020爱思唯尔B. V.保留所有权利。
Aims: Sleep-disordered breathing (SDB) is a well-known risk factor for cardiovascular outcomes. Studies of patients with SDB have identified frequent night-time urination as a manifestation related to SDB. We aimed to clarify whether night-time frequency of urination is independently associated with SDB in a general population. We also investigated whether night-time frequency of urination can help presumptive diagnose SDB.Methods: Study participants consisted of 7151 community residents. Oxygen saturation during sleep was measured for four nights using a pulse oximeter. SDB was defined as >= 15 events per hour in which oxygen desaturation exceeded or equal to 3% during an actigraphy-determined sleep period. Night-time frequency of urination was recorded for one week using a sleep diary.Results: Significant positive correlations were evident between night-time frequency of urination and SDB (none, 5.8%; once/night, 14.1%; twice/night, 20.1%; thrice/night, 28.7%; >thrice/night, 44.1%, P < 0.001). This association was independent of possible covariates, including sleep duration (adjusted odds ratio: once/night = 1.50, twice/night = 2.15, thrice/night = 3.07, >thrice/night = 3.73, P < 0.001). Other factors significantly associated with SDB were age, sex, obesity, observation of sleep apnea, and short sleep duration. The area under the curve of the risk score for SDB consisting of these conventional six items (0.834) significantly improved (0.842, P = 0.001) when night-time frequency of urination was considered as a risk score item.Conclusion: Night-time frequency of urination was associated with SDB. Our findings suggest that the urination frequency should be considered a manifestation of SDB even in a general population. (C) 2020 Elsevier B.V. All rights reserved.