Clinicopathologic Characteristics and Prognosis of Breast Cancer Patients Associated with Pregnancy and Lactation: Analysis of Case‐Control Study in Japan
Clinicopathologic Characteristics and Prognosis of Breast Cancer Patients Associated with Pregnancy and Lactation: Analysis of Case‐Control Study in Japan
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妊娠期和哺乳期乳腺癌患者的临床病理特征和预后：日本病例对照研究分析
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发表时间：
1992
期刊：
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通讯作者：
H. Sonoo
中科院分区：
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作者：
T. Ishida;T. Yokoe;F. Kasumi;G. Sakamoto;M. Makita;T. Tominaga;K. Simozuma;K. Enomoto;K. Fujiwara;T. Nanasawa;T. Fukutomi;T. Hirota;M. Fukuda;S. Miura;H. Koyama;H. Inaji;H. Sonoo
通过一项匹配的非妊娠和非哺乳期乳腺癌患者的病例对照研究，明确了与妊娠和哺乳期相关的乳腺癌患者的临床病理特征和预后。日本18家机构1970 - 1988年间共收集了192例在妊娠期（72例）和哺乳期（120例）诊断为乳腺癌的受试者，占全部乳腺癌患者的0.76%。研究对象的症状持续时间较长，肿瘤大小较大。虽然无病期较对照组长，但生存时间较对照组短。组织学类型无特征性差异。血管侵犯和淋巴结转移在受试者中更为常见。雌激素受体和孕激素受体阳性率较低。研究患者的5年和10年生存率分别为65%和55%，这些生存率显著低于对照组（P < 0.001）。根据分期和淋巴结转移情况，患者的生存率较低。结果提示，在妊娠和哺乳期确诊的乳腺癌患者，由于发现和诊断的延误，大多处于较晚期，预后较差。因此，早期诊断和治疗对于改善妊娠期和哺乳期乳腺癌患者的预后具有重要意义。
Clinicopathologic characteristics and prognosis of breast cancer patients associated with pregnancy and lactation were clarified by means of a case‐control study of matched non‐pregnant and non‐lactating patients with breast cancer. From 18 institutions in Japan, a total of 192 subjects with breast cancer diagnosed during pregnancy (72 cases) and lactation (120 cases) were collected between 1970 and 1988, accounting for 0.76% of all breast cancer patients. The duration of symptoms was longer and tumor size was larger in the study subjects. Although the disease‐free interval was longer than that in the control patients, the survival time was shorter. There was no characteristic difference in histologic type. Vascular invasion and lymph node metastasis were found more frequently in the subjects. The positive rates of estrogen receptor and progesterone receptor were lower in the subjects. The 5‐ and 10‐year survival rates of the study patients were 65% and 55%, respectively, and these survivals were significantly lower than those of the control (P < 0.001). The survival rates were poorer in the subjects, in accordance with stage and lymph node metastasis. The results suggest that most of the patients with breast cancer diagnosed during pregnancy and lactation are in a more advanced stage because of a delay in detection and diagnosis, and hence have unfavorable prognosis. Therefore, it is important to diagnose and treat early for improvement of prognosis in patients with breast cancer during pregnancy and lactation.