Anatomical MRI of the developing human brain: What have we learned?
Anatomical MRI of the developing human brain: What have we learned?
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DOI：
10.1097/00004583-200109000-00009
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发表时间：
2001-09-01
影响因子：
13.3
通讯作者：
van Engeland, H
中科院分区：
文献类型：
--
作者：
Durston, S;Pol, HEH;van Engeland, H
目的：对儿童和青春期正常发育脑的磁共振成像(MRI)研究的现有文献进行综述和整合，探讨其对临床MRI研究的意义。方法：根据有关发育中人脑MRI的期刊文章中的报道，总结区域脑体积随年龄的变化和性别差异。结果：白质体积随年龄增长而增大。灰质体积在儿童时期增加，然后在成年前减少。平均而言，男孩的大脑比女孩大；在对大脑总体积进行校正后，女孩的尾状核相对较大，男孩的杏仁核相对较大。鉴于几乎所有儿童期起病的精神障碍在发病年龄、症状和患病率方面的性别相关差异，差异具有临床意义。注意力缺陷/多动障碍经常被用作展示这些观点的例子。结论：了解正常脑发育的发育轨迹和性别差异对于解释临床影像研究具有重要意义。
Objective: To critically review and integrate the existing literature on magnetic resonance imaging (MRI) studies of the normally developing brain in childhood and adolescence and discuss the implications for clinical MRI studies. Method: Changes in regional brain volume with age and differences between the sexes are summarized from reports in refereed journal articles pertaining to MRI of the developing human brain. Results: White matter volume increases with age. Gray matter volumes increase during childhood and then decrease before adulthood. On average, boys have larger brains than girls; after correction for overall brain volume the caudate is relatively larger In girls, and the amygdala is relatively larger in boys. Differences are of clinical interest given gender-related differences in the age of onset, symptomatology, and prevalence noted for nearly all childhood-onset psychiatric disorders. Attention-deficit/hyperactivity disorder is frequently used as an example to demonstrate these points. Conclusions: Understanding the developmental trajectories of normal brain development and differences between the sexes is important for the interpretation of clinical imaging studies.