SEX-RELATED DIFFERENCES IN THE EFFECTS OF MORPHINE AND STRESS ON VISCERAL PAIN
SEX-RELATED DIFFERENCES IN THE EFFECTS OF MORPHINE AND STRESS ON VISCERAL PAIN
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DOI：
10.1016/0028-3908(89)90197-4
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发表时间：
1989-09-01
影响因子：
4.7
通讯作者：
ANDRESTRELLES, F
中科院分区：
文献类型：
--
作者：
BAAMONDE, AI;HIDALGO, A;ANDRESTRELLES, F
在四组大鼠中研究了吗啡（在没有压力的情况下和一种纳洛酮敏感的游泳压力后）对腹腔注射高渗盐水引起的疼痛性收缩的影响：正常周期的动情期雌性大鼠、雄性大鼠、卵巢切除雌性大鼠和接受持续光照的雌性大鼠，以诱导高雌激素血症状态。在没有游泳应激的情况下，雄性动物对吗啡的敏感性最大（即以最小剂量产生镇痛作用）。游泳应激后，雄性和卵巢切除大鼠表现出较低的敏感性，吗啡的镇痛作用比正常女性在发情期，而女性进行恒定的光敏感性较低。在自然发情的雌性动物中，但在其他组中没有，小剂量（0.05 mg/kg）的吗啡，矛盾地大大减少了游泳应激的镇痛作用。这些结果显示了性相关因素在内脏痛对吗啡和应激的敏感性中的重要性。内源性雄激素和雌激素可能具有选择性作用。
The effect of morphine (in the absence of stress and after a type of naloxone-sensitive swim-stress) on the painful contractions induced by intraperitoneal injection of hypertonic saline was studied in four groups of rats: normally cycling females in oestrus, males, ovariectomized females and females subjected to constant light, to induce a hyperoestrogenemic state. In the absence of swim-stress, the sensitivity to morphine was maximum for males (i.e. analgesia was produced with the smallest doses). After swim-stress, both males and ovariectomized rats showed less sensitivity to the analgesic effect of morphine than normal females in oestrus, while females subjected to constant light were less sensitive. In females in natural oestrus, but not in the other groups, small doses (0.05 mg/kg) of morphine, paradoxically reduced the analgesic effect of swim-stress considerably. These results show the importance of sex-related factors in the sensitivity of visceral pain to morphine and stress. A selective role for endogenous androgens and oestrogens is likely.