INHIBITION OF CORONARY BLOOD-FLOW BY A VASCULAR WATERFALL MECHANISM
INHIBITION OF CORONARY BLOOD-FLOW BY A VASCULAR WATERFALL MECHANISM
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DOI：
10.1161/01.res.36.6.753
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发表时间：
1975-01-01
影响因子：
20.1
通讯作者：
KIRK, ES
中科院分区：
文献类型：
--
作者：
DOWNEY, JM;KIRK, ES
研究了心脏收缩抑制冠状动脉血流的机制。左冠状动脉的一个分支最大限度地扩张与腺苷输注，并获得的压力-流量关系的跳动和停止状态。停搏状态的压力-流量曲线向更高的压力移动，并且在高于峰值心室压力的压力范围内是线性的，并且平行于停搏状态。在此范围之下，打浆状态的曲线向制动状态的曲线收敛，并向压力轴凸出。这些结果与冠状动脉血管模型进行了比较，该模型由许多平行通道组成，每个通道通过形成血管瀑布响应局部心肌内压力。当模型中的心肌内压从心外膜处的零值分配到内膜处的心室峰压时，得到与实验相似的压力-流量曲线。因此，我们得出结论，收缩期抑制冠状动脉灌注的血管瀑布的形成和心肌内的压力，负责这种抑制不显着超过峰值心室压力。
The mechanism whereby systole inhibits coronary blood flow was examined. A branch of the left coronary artery was maximally dilated with an adenosine infusion, and the pressure-flow relationship was obtained for beating and arrested states. The pressure-flow curve for the arrested state was shifted toward higher pressures and in the range of pressures above peak ventricular pressure was linear and parallel to that for the arrested state. Below this range the curve for the beating state converged toward that for the arrested state and was convex to the pressure axis. These results were compared with a model of the coronary vasculature that consisted of numerous parallel channels, each responding to local intramyocardial pressure by forming vascular waterfalls. When intramyocardial pressure in the model was assigned values from zero at the epicardium to peak ventricular pressure at the endocardium, pressure-flow curves similar to the experimental ones resulted. Thus, we conclude that systole inhibits coronary perfusion by the formation of vascular waterfalls and that the intramyocardial pressures responsible for this inhibition do not significantly exceed peak ventricular pressure.