Differential impairment of delayed matching in monkeys by scopolamine and scopolamine methylbromide
Differential impairment of delayed matching in monkeys by scopolamine and scopolamine methylbromide
复制标题
东莨菪碱和甲基溴东莨菪碱对猴子延迟配型的差异性损害
DOI：
10.1007/bf00404606
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
J. Carley
中科院分区：
文献类型：
--
作者：
Z. Bohdanecký;M. Jarvik;J. Carley
本文研究了氢溴酸东莨菪碱及其季铵类似物甲基溴化东莨菪碱两种剂量（0.2和0.4mg/kg）对猴延迟匹配行为的影响。东莨菪碱在较低的剂量显着降低只有性能率，而在较高的剂量，它降低了性能率和百分比准确性的猴子在前两个周期的实验。另一方面，甲基溴东茛菪碱（两种剂量）均抑制反应率，但在实验结束时（即给药后10小时以上）效果更加明显。这些结果表明，甲基溴化东莨菪碱可能通过血脑屏障影响行为，从而损害动物的反应率。
The effects of scopolamine hydrobromide and its quaternary analogue, scopolamiae methylbromide, in two doses (0.2 and 0.4 mg/kg) upon delayed matching performance was studied in monkeys. Scopolamine in the lower dose depressed significantly only performance rate, while in the higher dose it depressed both performance rate and percentage accuracy of the monkeys during the first two cycles of the experiment. On the other hand, scopolamine methylbromide (both doses) depressed just responding rate, but the effect was more pronounced towards the end of the experiment (i.e. after more than 10 hr after drug administration). These results indicate the ability of scopolamine methylbromide to influence behavior possibly by passing the blood brain barrier and thus impair the response rate of the animals.