Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
复制标题
银屑病全基因组关联研究确定了 1q21 LCE 基因簇内的易感性变异。
DOI：
10.1038/ng.310
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发表时间：
2009-02-01
期刊：
影响因子：
30.8
通讯作者：
Liu, Jian-Jun
中科院分区：
文献类型：
--
作者：
Zhang, Xue-Jun;Huang, Wei;Liu, Jian-Jun
我们报告了第一个在中国人群中进行的大型全基因组关联研究（GWAS），使用两阶段病例对照设计确定银屑病的易感性变异。在第一阶段，我们使用Illumina Human 610-Quad BeadChips对中国汉族血统的1，139例病例和1，132例对照进行了全基因组关联分析。在第二阶段，我们在两个独立的样本中复制了中国汉族血统的5，182例病例和6，516例对照，以及中国维吾尔族血统的539例病例和824例对照。除了两个已知的易感位点MHC的强复制外，（rs1265181，P 1.93 x 10（-208），OR = 22.62）和IL 12B（rs3213094，P-组合= 2.58 × 10（-26），OR = 0.78），我们在1 q21上的LCE基因簇中鉴定了一个新的易感位点（rs 4085613，P-组合= 6.69 × 10（-30），OR = 0.76）。
We report the first large genome-wide association study (GWAS) in a Chinese population to identify susceptibility variants for psoriasis using a two-stage case-control design. In the first stage, we carried out a genome-wide association analysis in 1,139 cases and 1,132 controls of Chinese Han ancestry using Illumina Human 610-Quad BeadChips. In the second stage, we took top SNPs forward for replication in two independent samples of 5,182 cases and 6,516 controls of Chinese Han ancestry, and 539 cases and 824 controls of Chinese Uygur ancestry. In addition to the strong replication for two known susceptibility loci MHC (rs1265181, P 1.93 x 10(-208), OR = 22.62) and IL12B (rs3213094, P-combined = 2.58 x 10(-26), OR = 0.78), we identified a new susceptibility locus within the LCE gene cluster on 1q21 (rs4085613, P-combined = 6.69 x 10(-30), OR = 0.76).