In vivo evaluation of stent strut distribution patterns in the bioabsorbable everolimus-eluting device: an OCT ad hoc analysis of the revision 1.0 and revision 1.1 stent design in the ABSORB clinical trial
In vivo evaluation of stent strut distribution patterns in the bioabsorbable everolimus-eluting device: an OCT ad hoc analysis of the revision 1.0 and revision 1.1 stent design in the ABSORB clinical trial
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DOI：
10.4244/eijv5i8a157
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发表时间：
2010-04-01
期刊：
影响因子：
6.2
通讯作者：
Serruys, Patrick W.
中科院分区：
文献类型：
--
作者：
Okamura, Takayuki;Garg, Scot;Serruys, Patrick W.
目的：临床研究表明，完全生物吸收的依维莫司洗脱结构（BVS, revision 1.0）的可行性和安全性。然而，该研究也表明，与金属药物洗脱支架相比，BVS结构的急性和晚期后坐力更高。基于这些临床观察，我们为吸收队列B研究引入了支架设计的修改（BVS, revision 1.1），以减少后坐力。目的是比较BVS版本1.0（队列A）和BVS版本1.1（队列B）设计之间的体内支撑分布。方法和结果：OCT分析由两名独立的分析人员对来自吸收研究的每个队列的4名患者进行。在截面上评估支柱分布，并在纵向上逐帧分析。记录的变量包括杆间角、最大杆间角和与
Aims: The ABSORB Cohort A clinical study has shown the feasibility and safety of the fully bioabsorbable everolimus-eluting structure (BVS, revision 1.0). However, the study also demonstrated somewhat higher acute and late recoil with the BVS structure compared to metallic drug eluting stents. Based on these clinical observations, modifications to the stent design (BVS, revision 1.1) were introduced for the ABSORB Cohort B study in order to decrease recoil. The aim was to compare in vivo the strut distribution between the BVS revision 1.0 (Cohort A), and BVS revision 1.1 (Cohort B) designs.Methods and results: OCT analysis was performed by two independent analysts in four patients from each cohort of the ABSORB study. Strut distribution was assessed in cross-section, and longitudinally in a frame-by-frame analysis. Variables recorded included inter-strut angle, maximum inter-strut angle and number of frames with