Fluorescent ion-selective nanosensors for intracellular analysis with improved lifetime and size
Fluorescent ion-selective nanosensors for intracellular analysis with improved lifetime and size
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DOI：
10.1021/nl0707860
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发表时间：
2007-06-01
期刊：
影响因子：
10.8
通讯作者：
Clark, Heather A.
中科院分区：
文献类型：
--
作者：
Dubach, J. Matthew;Harjes, Daniel I.;Clark, Heather A.
我们描述了钠选择性聚合物纳米传感器的合成和表征，其改进了以前的无纤维纳米传感器的寿命和尺寸。超声处理用于形成包含离子传感所需的所有组分的聚合物纳米球。尽管尺寸很小（约120 nm），但这些传感器在溶液中的寿命约为一周。表面涂层还针对稳定性、生物相容性和易于化学改性进行了优化。
We describe the synthesis and characterization of sodium-selective polymeric nanosensors that improves upon the lifetime and size of previous fiberless nanosensors. Sonication is used to form the polymer nanospheres that contain all the components needed for ion sensing. Even though the size is small (approximately 120 nm), the lifetime of these sensors in solution is on the order of a week. The surface coating has also been optimized for stability, biocompatibility, and ease of chemical modification.