ROLE OF PROTEIN OXIDATION IN AGING AND IN AGE-ASSOCIATED NEURODEGENERATIVE DISEASES
ROLE OF PROTEIN OXIDATION IN AGING AND IN AGE-ASSOCIATED NEURODEGENERATIVE DISEASES
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DOI：
10.1016/0024-3205(94)00390-4
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发表时间：
1994-01-01
期刊：
影响因子：
6.1
通讯作者：
CARNEY, AM
中科院分区：
文献类型：
--
作者：
CARNEY, JM;CARNEY, AM
衰老和与年龄相关的神经退行性疾病被认为是抗氧化状态和活性氧产生变化的结果。对人类的研究已经证明，来自神经正常人和来自患有不同神经疾病（阿尔茨海默氏病、帕金森氏病和亨廷顿氏病）的个体的脑的氧化蛋白质显著增加。这些病症和脑缺血的临床前模型证明了蛋白质氧化在这些神经退行性疾病的初始步骤中的主要作用。衰老是这些疾病发展的一个危险因素，也与大脑抗氧化防御系统的减少有关。有人提出，自由基在那些最终导致神经元死亡的生化事件的启动中起主要作用。
Aging and age-associated neurodegenerative diseases have been proposed to be the result of changes in a in anti-oxidant status and in the production of reactive oxygen species. Studies in humans have demonstrated a significant increase in oxidized protein from brains of neurological normals and from individuals with different neurological diseases (Alzheimer's, Parkinson's and Huntington's Disease). Preclinical models of these conditions and of cerebral ischemia demonstrate the primary role of protein oxidation in the initial steps of these neurodegenerative diseases. Aging is a risk factor in the development of these diseases and is also associated with a decrease in the anti-oxidant defense systems of the brain. It is proposed that free radicals play a primary role in the initiation of those biochemical events that ultimately lead to the death of the neuron.