Integrated multimodal-catheter imaging unveils principal relationships among ventricular electrical activity, anatomy, and function.
Integrated multimodal-catheter imaging unveils principal relationships among ventricular electrical activity, anatomy, and function.
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集成多模态导管成像揭示了心室电活动、解剖结构和功能之间的主要关系。
DOI：
10.1152/ajpheart.01297.2006
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Khoury,DirarS
中科院分区：
文献类型：
--
作者：
Rao,Liyun;Ling,Yuesheng;He,Renjie;Gilbert,AprilL;Frangogiannis,NikolaosG;Wang,Jianwen;Nagueh,SherifF;Khoury,DirarS
Multiple imaging modalities are employed independent of one another while managing complex cardiac arrhythmias. To combine electrical, anatomical, and functional imaging in a single catheter system, we developed a balloon catheter that carried 64 electrodes on its surface and an intracardiac echocardiography (ICE) catheter through a central lumen. The catheter system was inserted, and the balloon was inflated inside the left ventricle (LV) of eight dogs with 6-wk-old infarction, created by occlusion in the left anterior descending coronary artery. Anatomy was constructed by ICE imaging (9 MHz) through the balloon. Single-beat noncontact mapping (NCM) was performed via the multielectrode array to reconstruct unipolar endocardial electrograms during sinus rhythm. Standard contact mapping (CM) of the endocardium was also carried out for reference. Myocardial infarction in anterior LV extending from the middle to apical regions was localized both by ICE and NCM and validated by CM and pathology. The overall difference in the activation times between NCM and CM was 3 ± 1 ms. Unipolar voltage in infarcted middle anterior LV was smaller than the voltage in normal middle inferior LV both by NCM (11 ± 4 vs. 16 ± 3 mV;P= 0.002) and CM (11 ± 3 vs. 20 ± 4 mV;P< 0.001). Unipolar voltage was also inversely related to infarct transmurality, both by NCM (r= −0.87;P= 0.005) and CM (r= −0.94;P< 0.001). The infarct area by ICE (7.7 ± 2.9 cm2) was in agreement with CM (bipolar voltage, <1 mV; and area, 7.6 ± 3.3 cm2;r= 0.80;P= 0.016). Meanwhile, the voltage threshold that depicted the infarct area by NCM was directly related to the smallest unipolar voltage reconstructed within the infarct (r= 0.96;P< 0.001). In conclusion, combining NCM and ICE imaging in a single catheter system is feasible. The preclinical development of such an integrated system and its evaluation in experimental myocardial infarction demonstrate capabilities for single-beat mapping at multiple sites as well as the online assessment of anatomy and myocardial function.
