SYNTHESIS AND CHEMISTRY OF "7-AMINO-4-(TRIFLUOROMETHYL)COUMARIN AND ITS AMINO-ACID AND PEPTIDE DERIVATIVES
SYNTHESIS AND CHEMISTRY OF "7-AMINO-4-(TRIFLUOROMETHYL)COUMARIN AND ITS AMINO-ACID AND PEPTIDE DERIVATIVES
复制标题
DOI：
10.1021/jo01300a003
复制
发表时间：
1980-01-01
影响因子：
3.6
通讯作者：
SMITH, RE
中科院分区：
文献类型：
--
作者：
BISSELL, ER;MITCHELL, AR;SMITH, RE
The synthesis and purification of 7-amino-4-(trifluoromethyl)coumarin, a novel fluorescent marker for the sensitive detection of proteinases, were investigated. Two byproducts, 7-hydroxy-4-(trifluoromethyl)-2-quinolone and 2-ethoxy-7-hydroxy-4-(trifluoromethyl)quinoline, were isolated and identified. 7-Methoxy-4-(trifluoromethyl)-2-quinolone was also prepared. Amino acid and peptide derivatives prepared by solution methods using the stepwise approach included 7-(L-leucinamido)-, 7-(D-alanyl-L-leucyl-L-lysinamido)-, 7-(D-valyl-L-leucyl-L-lysinamido)-, and 7-(N.alpha.-Z-glycylglycyl-L-argininamido)-4-(trifluoromethyl)coumarins. [The potential for using proteinase levels in assessing neoplasia and other diseases in humans is discussed.].
