DEPENDENCE OF PARACETAMOL ABSORPTION ON RATE OF GASTRIC EMPTYING
DEPENDENCE OF PARACETAMOL ABSORPTION ON RATE OF GASTRIC EMPTYING
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DOI：
10.1111/j.1476-5381.1973.tb08339.x
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发表时间：
1973-01-01
影响因子：
7.3
通讯作者：
TOTHILL, P
中科院分区：
文献类型：
--
作者：
HEADING, RC;NIMMO, J;TOTHILL, P
1.本文对14例康复期住院患者口服扑热息痛1.5g后，直接测定胃排空率，并研究其吸收情况。2.快速胃排空与早期出现的对乙酰氨基酚高峰血浆浓度相关，而当胃排空缓慢时，峰浓度较低且出现较晚。3.胃排空率与对乙酰氨基酚及其代谢产物的0-4和0-24 h尿排泄量之间存在显著相关性。4.在5例胃排空异常缓慢的患者中，对乙酰氨基酚的平均最大血浆浓度和0-4和0-24 h尿排泄量显著低于7例胃排空率正常的患者，而达到最大血浆浓度所需的时间较长。5.胃排空率的个体差异可能导致许多药物的吸收不同。
1. The rate of gastric emptying was measured directly in 14 convalescent hospital patients and paracetamol absorption was studied following an oral dose of 1·5 g. 2. Rapid gastric emptying was associated with the early appearance of high peak plasma paracetamol concentrations whereas peak concentrations were low and occurred late when gastric emptying was slow. 3. There was a significant correlation between the rate of gastric emptying and the 0-4 and 0-24 h urinary excretion of paracetamol and its metabolites. 4. In five patients with abnormally slow gastric emptying the mean maximum plasma concentration and 0-4 and 0-24 h urinary excretion of paracetamol were significantly lower than in seven patients with normal gastric emptying rates while the time taken to reach maximum plasma concentrations was longer. 5. Individual differences in the rate of gastric emptying may contribute to variable absorption of many drugs.