Studies in multiple sclerosis IV. "Encephalitis" and sclerotic plaques produced by venular obstruction
Studies in multiple sclerosis IV. "Encephalitis" and sclerotic plaques produced by venular obstruction
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DOI：
10.1001/archneurpsyc.1935.02250170015002
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发表时间：
1935-05-01
影响因子：
--
通讯作者：
Putnam, TJ
中科院分区：
文献类型：
--
作者：
Putnam, TJ
本发明描述了一种用各种物质在狗脑中产生静脉、小静脉和毛细血管阻塞的方法，所产生的组织学变化取决于所使用的物质。通过使用各种油，可能会产生早期阶段非常类似于非化脓性脑炎的病变。“也许反应的温和程度可能会随着时间的推移而消退。后期（最多10个月）的病变由脱髓鞘斑块组成，几乎完全保留了轴柱，并伴有局限于白色物质的致密纤维胶质增生。这些病变与人类多发性硬化症中所见的许多病变之间的相似性是如此惊人，以至于似乎几乎不可避免地得出这样的结论：小静脉阻塞是典型硬化斑块形成的基本直接前因。其他事实指向相同的结论简要回顾。
A method is described for producing venous, venular and capillary obstruction with various substances in the brains of dogs, the histologic changes produced depending on the substance used. By the use of various oils, lesions may be produced which in their early stages closely resemble those of non-suppurative "encephalitis." Probably milder degrees of the reaction may regress in time. The later stages (up to 10 mos.) of the lesions consist of plaques of demyelinization with practically complete preservation of the axis-cylinders and with dense fibrous gliosis confined to the white matter. The similarity between such lesions and many of those seen in cases of multiple sclerosis in man is so striking that the conclusion appears almost inevitable that venular obstruction is the essential immediate antecedent to the formation of typical sclerotic plaques. Other facts pointing to the same conclusion are briefly reviewed.