Effects of Each Phase of Anterior Cruciate Ligament Reconstruction Surgery on Joint Contracture in Rats
Effects of Each Phase of Anterior Cruciate Ligament Reconstruction Surgery on Joint Contracture in Rats
复制标题
前交叉韧带重建手术各阶段对大鼠关节挛缩的影响
DOI：
10.1080/08941939.2021.1985193
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发表时间：
2021
影响因子：
1.9
通讯作者：
Yamaoka Kaoru
中科院分区：
文献类型：
--
作者：
Kaneguchi Akinori;Ozawa Junya;Minamimoto Kengo;Yamaoka Kaoru
虽然前十字韧带重建手术会导致关节痉挛，但其机制尚不清楚。我们的目的是评估韧带切断和重建手术的各个阶段对肌挛缩形成的影响。材料和方法根据接受的治疗将大鼠分为假手术组(关节切断组)、韧带切断组、韧带切断加打骨术组和韧带重建组。手术是在右膝上进行的。结果术后7d和28d，假手术组和韧带切断组肌切开术前活动度均受到限制，主要表现为肌源性肌挛缩，而钻骨和重建组表现更为明显。在两个时间点，骨钻和重建组均检测到肌切开术后活动受限，代表关节源性肌挛缩，而假手术组和韧带横断组则未检测到。术后3d，三组均有较大的血块形成，但只有骨钻和骨重建组关节肿胀明显。术后7d，骨钻孔组和重建组关节囊内炎症细胞浸润最为明显，关节囊纤维化在术后7d和28d也最为明显。结论前十字韧带重建术后肌源性肌挛缩是关节切开引起的，骨钻孔加重了肌源性肌挛缩；(2)关节源性肌挛缩主要是由于骨钻孔引起的，从而引发炎症-纤维化级联反应。
BackgroundAlthough anterior cruciate ligament reconstruction surgery is known to cause joint contracture, the mechanisms of this process are unknown. We aimed to assess the effects of transection of this ligament and each phase of reconstruction surgery on contracture formation.Materials and methodsRats were divided into groups according to treatment received: sham (arthrotomy), ligament transection, ligament transection plus bone drilling, and ligament reconstruction. Surgery was performed on the right knee. Untreated left knees in the sham group were used as controls.ResultsAt 7 and 28 d post-surgery, range of motion before myotomy, mainly representing myogenic contracture, was restricted in the sham and ligament transection groups, and more so in the bone drilling and reconstruction groups. Restricted range of motion after myotomy, representing arthrogenic contracture, was detected at both timepoints in the bone drilling and reconstruction groups, but not in the sham or ligament transection groups. At 3 d post-surgery, although a large blood clot was observed in all three treatment groups, only the bone drilling and reconstruction groups showed significant joint swelling. At 7 d post-surgery, inflammatory-cell infiltration into the joint capsule was most apparent in the bone drilling and reconstruction groups, and joint capsule fibrosis was also most apparent in these groups at 7 and 28 d post-surgery.ConclusionsOur results suggest that (1) myogenic contracture after anterior cruciate ligament reconstruction is caused by arthrotomy and aggravated by bone drilling, and (2) arthrogenic contracture is mostly due to bone drilling, which triggers an inflammation–fibrosis cascade.
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DOI：
10.1210/jcem.83.6.4848
发表时间：
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期刊：
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影响因子：
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影响因子：
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