Stereolithographic 4D Bioprinting of Multiresponsive Architectures for Neural Engineering
Stereolithographic 4D Bioprinting of Multiresponsive Architectures for Neural Engineering
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DOI：
10.1002/adbi.201800101
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发表时间：
2018-09-01
影响因子：
4.1
通讯作者：
Zhang, Lijie Grace
中科院分区：
文献类型：
--
作者：
Miao, Shida;Cui, Haitao;Zhang, Lijie Grace
4D打印代表了在组织工程、生物医学设备和软机器人等方面应用的最先进的制造技术之一。在这项研究中，一种新的多响应架构是通过基于立体光刻的4D打印开发的，其中应用了应力诱导形状变换的通用概念来实现4D重编程。光诱导的梯度内应力，然后由随后的溶剂诱导的松弛，驱动一个自主的和可逆的变化的编程配置后，印刷，采用和调查的深度和细节。此外，所制造的结构具有形状记忆特性，提供了多种形状变化的特征。使用这种新颖的多响应4D技术，在石墨烯混合4D构造上展示了概念验证的智能神经引导导管，该石墨烯混合4D构造为神经再生提供了出色的多功能特性，包括物理引导、化学提示、动态自增强和无缝集成。通过采用这种制造技术，创建了多响应智能架构，并展示了应用潜力，这项工作为在各种高价值研究领域真正启动4D打印铺平了道路。
4D printing represents one of the most advanced fabrication techniques for prospective applications in tissue engineering, biomedical devices, and soft robotics, among others. In this study, a novel multi-responsive architecture is developed through stereolithography-based 4D printing, where a universal concept of stress-induced shape transformation is applied to achieve the 4D reprogramming. The light-induced graded internal stress followed by a subsequent solvent-induced relaxation, driving an autonomous and reversible change of the programmed configuration after printing, is employed and investigated in depth and details. Moreover, the fabricated construct possesses shape memory property, offering a characteristic of multiple shape change. Using this novel multiple responsive 4D technique, a proof-of-concept smart nerve guidance conduit is demonstrated on a graphene hybrid 4D construct providing outstanding multifunctional characteristics for nerve regeneration including physical guidance, chemical cues, dynamic self-entubulation, and seamless integration, By employing this fabrication technique, creating multiresponsive smart architectures, as well as demonstrating application potential, this work paves the way for truly initiation of 4D printing in various high-value research fields.