Two new isochromane derivatives penisochromanes A and B from ascidian-derived fungus Penicillium sp. 4829
Two new isochromane derivatives penisochromanes A and B from ascidian-derived fungus Penicillium sp. 4829
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来自海鞘衍生真菌青霉属的两种新异色满衍生物 penisochromanes A 和 B。
DOI：
10.1080/14786419.2018.1470173
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发表时间：
2019-05-03
影响因子：
2.2
通讯作者：
He, Jianguo
中科院分区：
文献类型：
--
作者：
Niaz, Shah-Iram;Zhang, Panpan;He, Jianguo
从海鞘真菌Penicillium sp.中分离得到7个多酮类化合物，其中包括2个新的异色胺类化合物--偏异色胺A和B(1和2)，以及5个已知化合物。4829号。通过广泛的波谱分析确定了它们的结构。化合物1和3的结构经X-射线单晶测定得到进一步确证。化合物1和2是第一个天然来源的具有三个相邻含氧取代基的异色胺的例子。化合物4对两种革兰氏阳性菌金黄色葡萄球菌和枯草芽孢杆菌具有选择性活性，其MIC值分别为6.25和12.5mU M。
Seven polyketides, including two new isochromanes, penisochromanes A and B (1 and 2), as well as five known compounds were obtained from an ascidian-derived fungus Penicillium sp. 4829. Their structures were identified by extensive spectroscopic analyses. The structures of compounds 1 and 3 were further determined by the X-ray crystallography. Compounds 1 and 2 were the first example of isochromane with three adjacent oxy substituents in natural source. Compound 4 exhibited selective activities against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, with MIC values 6.25 and 12.5 mu M, respectively.[GRAPHICS].