Cyclothymic and hyperthymic temperaments may predict bipolarity in major depressive disorder: a supportive evidence for bipolar II1/2 and IV.
Cyclothymic and hyperthymic temperaments may predict bipolarity in major depressive disorder: a supportive evidence for bipolar II1/2 and IV.
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DOI：
10.1016/j.jad.2010.07.016
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发表时间：
2011-03
影响因子：
6.6
通讯作者：
Shinjiro Goto;T. Terao;N. Hoaki;Yumei Wang
中科院分区：
文献类型：
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作者：
Shinjiro Goto;T. Terao;N. Hoaki;Yumei Wang
背景：软双极谱的概念尚未得到充分的证实。本研究的目的是探讨双相情感障碍II1/2和IV概念的有效性。方法选取连续门诊患者46例。采用孟菲斯、比萨、巴黎和圣地亚哥气质评估问卷（tempa）记录每位患者的个性气质。双相i /2的操作定义为伴有循环胸腺气质的抑郁症患者，双相IV的操作定义为伴有高胸腺气质的抑郁症患者。最后，研究药物反应。结果dsm - iv - tr诊断为双相情感障碍I型（N=1）、双相情感障碍II型（N=9）、重度抑郁症（N=34）和未明确诊断的抑郁症（N=2）。除了一名同时患有循环胸腺和高亢胸腺的I型双相患者外，II型1/2 （N=32）和IV型（N=13）以及II型（N=9）患者被归为软双相谱系，尽管有相当大的重叠。软双相和单极抑郁症的分类显著预测抑郁、周期性、易怒和焦虑的气质。此外，接受锂治疗的软双相患者的缓解程度明显高于未接受锂治疗的患者。此外，与没有使用选择性血清素再摄取抑制剂（SSRIs）的患者相比，使用选择性血清素再摄取抑制剂（SSRIs）的患者有明显降低缓解的趋势。局限性：本研究为横断面研究，受试者数量相对较少。结论循环胸腺和亢进胸腺可能预示双相情感障碍，支持双相情感障碍II1/2和IV概念的有效性。
BACKGROUNDThe concept of soft bipolar spectrum has not been fully confirmed. The aim of the present study is to investigate the validity of bipolar II1/2 and IV concept.METHODSThe subjects were 46 consecutive outpatients. The individual temperament of each patient was recorded using the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire (TEMPS-A). The operational definition of bipolar II1/2 was those who had depression with cyclothymic temperament and that of bipolar IV was those who had depression with hyperthymic temperament. Finally, drug responses were investigated.RESULTSDSM-IV-TR diagnoses were bipolar I (N=1), bipolar II (N=9), major depressive disorder (N=34) and depressive disorder not otherwise specified (N=2). Excluding one bipolar I patient, who had both cyclothymic and hyperthymic temperaments, patients with bipolar II1/2 (N=32) and IV (N=13) as well as bipolar II (N=9) were classified into the soft bipolar spectrum, although there was considerable overlap. The categorization of soft bipolar spectrum and unipolar depression significantly predicted depressive, cyclothymic, irritable, and anxious temperaments. Moreover, soft bipolar spectrum patients with lithium treatment were significantly more in remission than those without lithium treatment. In addition, more of those with selective serotonin reuptake inhibitors (SSRIs) had a significant tendency to lower remission than those without SSRIs.LIMITATIONSThis is a cross-sectional study with a relatively small number of subjects.CONCLUSIONSThe present findings suggest that cyclothymic and hyperthymic temperaments may predict bipolarity, and the validity of bipolar II1/2 and IV concept is supported.