Improvement on stability, loading capacity and sustained release of rhamnolipids modified curcumin liposomes
Improvement on stability, loading capacity and sustained release of rhamnolipids modified curcumin liposomes
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鼠李糖脂修饰姜黄素脂质体稳定性、载量及缓释性能的提高
DOI：
10.1016/j.colsurfb.2019.110460
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发表时间：
2019-11-01
影响因子：
5.8
通讯作者：
Liu, Wei
中科院分区：
文献类型：
--
作者：
Cheng, Ce;Wu, Zhihua;Liu, Wei
利用鼠李糖脂修饰脂质体（RL-Lps）制备了一种新型的姜黄素无胆固醇给药系统。与纯脂质体相比，鼠李糖脂的掺入增加了脂质体的球形度，减小了尺寸，并降低了脂质体的多分散性。RL-LPS的环境稳定性分析表明，它们在宽范围的pH（2-3和5-8）、离子强度（0-200 mM）和加速离心条件下具有良好的长期稳定性。姜黄素修饰的鼠李糖脂脂质体（Cur-RL-Lps）具有较高的包封率（LE > 90%）和载药量（LC > 3.5%）。姜黄素包封在Cur-RL-LPS中后，其热稳定性和光化学稳定性得到改善。体外释放研究表明，当鼠李糖脂掺入脂质体中时，姜黄素的持续释放被延长。本研究显示，鼠李糖脂作为脂质体传递系统在功能性食品、膳食补充剂和药物制剂中具有很大的应用潜力。
A novel cholesterol-free curcumin delivery system was fabricated by rhamnolipids modified liposomes (RL-Lps). The incorporation of the rhamnolipids increased the sphericity, reduced the size, and decreased the polydispersity of the liposomes compared with pure liposomes (Lps). Analysis of the environmental stability of the RL-Lps showed they have good long-term stability over a wide range of pH (2-3 and 5-8), ionic strengths (0-200 mM), and accelerated centrifugal conditions. The curcumin-loaded rhamnolipids modified liposomes (Cur-RL-Lps) could be prepared with a relatively high loading efficiency (LE > 90%) and loading capacity (LC > 3.5%). The thermal and photochemical stability of the curcumin was improved after encapsulation in the Cur-RL-Lps. In vitro release studies indicated that the sustained release of the curcumin was prolonged when rhamnolipids were incorporated into the liposomes. This study shows that rhamnolipids have great potential for liposomal delivery system suitable for utilization in functional foods, dietary supplements, and pharmaceutical preparations.