Empirically-derived response trajectories of intensive residential treatment in obsessive-compulsive disorder: A growth mixture modeling approach.
Empirically-derived response trajectories of intensive residential treatment in obsessive-compulsive disorder: A growth mixture modeling approach.
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强迫症的经验衍生的强化住宅治疗的反应轨迹：一种生长混合物建模方法。
DOI：
10.1016/j.jad.2018.11.075
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发表时间：
2019-02-15
影响因子：
6.6
通讯作者：
Elias, Jason A.
中科院分区：
文献类型：
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作者：
Falkenstein, Martha J.;Nota, Jacob A.;Krompinger, Jason W.;Schreck, Meghan;Garner, Lauryn E.;Potluri, Sriramya;Van Kirk, Nathaniel;Ponzini, Gabriella;Tifft, Eric;Brennan, Brian P.;Mathes, Brittany;Cattie, Jordan;Crosby, Jesse M.;Elias, Jason A.
背景本研究调查了严重强迫症（OCD）成人的自然主义强化/住院治疗（IRT）计划中治疗反应的不同轨迹。我们假设：（1）不同的轨迹将出现和（2）人口统计学变量，精神病合并症，强迫症症状亚型，自知力水平，以前的暴露和反应预防（ERP）治疗，和生活质量，将差异预测分配到这些trajectors.MethodsParticipants包括305个人与原发性强迫症承认的IRT.ResultsTwo轨迹出现在治疗的前八周的过程中，绝大多数参与者表现出治疗反应。第一个轨迹（96%，n = 292）显示阴性、线性治疗反应（也称为“线性反应者”）和入院时更严重的强迫症症状。第二组（4%，n = 13）入院时强迫症症状较轻，在治疗过程中症状总体上没有显著变化。更具体地，该第二轨迹或“U形响应者”显示出在治疗的第四周的非显著线性响应，随后在第五周中症状略微增加。分配到这些类是没有差异预测的假设predictor variables.LimitationsOur最终模型有不一致的拟合指数和小类患病率的U形响应者组，因此，模型选择的基础上，两个拟合指数和实质性的meanings.ConclusionsThis study emprically得出两个不同的轨迹强迫症症状的严重程度在IRT的过程中。这些发现有可能改善严重强迫症患者的IRT，并可能指导未来的调查，以最佳的ERP治疗强迫症。
BackgroundThis study investigated distinct trajectories of treatment response in a naturalistic intensive/residential treatment (IRT) program for adults with severe obsessive-compulsive disorder (OCD). We hypothesized that: (1) distinct trajectories would emerge and (2) demographic variables, psychiatric comorbidity, OCD symptom subtype, level of insight, previous exposure and response prevention (ERP) treatment, and quality of life, would differentially predict assignment to these trajectories.MethodsParticipants included 305 individuals with primary OCD admitted for IRT.ResultsTwo trajectories emerged over the course of the first eight weeks of treatment, with the vast majority of participants demonstrating treatment response. The first trajectory (96%,n= 292) showed a negative, linear treatment response (a.k.a. “linear responders”) and more severe OCD symptoms at admission. The second trajectory (4%,n= 13) had less severe OCD symptoms at admission and did not exhibit a significant overall change in symptoms over the course of treatment. More specifically, this second trajectory or “u-shaped responders” show a non-significant linear response through week four of treatment, followed by slightly increased symptoms in week five. Assignment to these classes was not differentially predicted by hypothesized predictor variables.LimitationsOur final model had inconsistent fit indices and small class prevalance of the u-shaped responder group; therefore, model selection was based on both fit indices and substantive meaning.ConclusionsThis study emprically derived two distinct trajectories of OCD symptom severity over the course of IRT. These findings have the potential to refine IRT for patients with severe OCD, and to potentially guide future investigation into the optimal delivery of ERP treatment for OCD generally.
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影响因子：
6.7
作者：
BECH, P;GRAM, LF;BOLWIG, TG
通讯作者：
BOLWIG, TG
影响因子：
10.3
作者：
Federici, Anita;Summerfeldt, Laura J.;Antony, Martin M.
通讯作者：
Antony, Martin M.
DOI：
10.1111/j.1751-9004.2007.00054.x
发表时间：
2008-01-01
影响因子：
4.6
作者：
Jung, Tony;Wickrama, K. A. S.
通讯作者：
Wickrama, K. A. S.
DOI：
10.1080/10705510701575396
发表时间：
2007-01-01
影响因子：
6
作者：
Nylund, Karen L.;Asparoutiov, Tihomir;Muthen, Bengt O.
通讯作者：
Muthen, Bengt O.
影响因子：
--
作者：
Bush, K;Kivlahan, DR;Bradley, KA
通讯作者：
Bradley, KA