Prolactin induces a hyperpolarising current in rat paraventricular oxytocinergic neurones.
Prolactin induces a hyperpolarising current in rat paraventricular oxytocinergic neurones.
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DOI：
10.1111/j.1365-2826.2011.02207.x
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发表时间：
2011-10
影响因子：
3.2
通讯作者：
Egli M
中科院分区：
文献类型：
--
作者：
Sirzen-Zelenskaya A;Gonzalez-Iglesias AE;Boutet de Monvel J;Bertram R;Freeman ME;Gerber U;Egli M
Prolactin and oxytocin are important reproductive hormones implicated in several common adaptive functions during pregnancy, pseudopregnancy and lactation. Recently, extracellular recordings of supraoptic neurons have shown that prolactin may modulate electrical activity of oxytocinergic neurons. However, no study has been conducted to establish whether prolactin directly influences this activity in oxytocinergic paraventricular neurons. Here we addressed this question by studying the effects of prolactin on the electrical activity and voltage-current relationship of identified paraventricular neurons in rat brain slices. Whole-cell recordings were obtained and neurons were classified on the basis of their morphological and electrophysiological fingerprint (magnocellular or parvicellular) and neuropeptide phenotype (oxytocinergic or non-oxytocinergic). We report that prolactin elicited a hyperpolarizating current in 37% of the neurons in this nucleus, of which the majority (67%) were identified as putative magnocellular oxytocin neurons and the reminder (33%) were regarded as oxytocin-negative, parvicellular neuroendocrine neurons. Our results suggest that, in addition to the well-established negative feedback loop between prolactin-secreting lactotrophs and dopaminergic neurons in the arcuate nucleus, an inhibitory feedback loop also exists between lactotrophs and oxytocinergic paraventricular neurons.
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影响因子：
4.8
作者：
BETHEA, CL;NEILL, JD
通讯作者：
NEILL, JD
影响因子：
3.2
作者：
CHIU, SF;WISE, PM
通讯作者：
WISE, PM
DOI：
10.1073/pnas.91.22.10384
发表时间：
1994-10-25
影响因子：
11.1
作者：
CLAPP, C;TORNER, L;DELAESCALERA, G
通讯作者：
DELAESCALERA, G
影响因子：
4.1
作者：
CRUMEYROLLEARIAS, M;LATOUCHE, J;HAOUR, F
通讯作者：
HAOUR, F
影响因子：
2.9
作者：
GHOSH, R;SLADEK, CD
通讯作者：
SLADEK, CD