Immune complexes in progressive systemic sclerosis (scleroderma).
Immune complexes in progressive systemic sclerosis (scleroderma).
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进行性系统性硬化症（硬皮病）中的免疫复合物。
DOI：
10.1002/art.1780251004
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发表时间：
1982
影响因子：
--
通讯作者：
Rodnan,GP
中科院分区：
文献类型：
--
作者：
Seibold,JR;MedsgerJr,TA;Winkelstein,A;Kelly,RH;Rodnan,GP
在92例进行性系统性硬化症患者中测定血清免疫复合物，发现水平升高如下：Raji细胞测定72%（Raji细胞链霉蛋白酶治疗后59%），琼脂糖凝胶电泳52%，C1q结合24%。其中43例（47%）在两项或两项以上检测中出现异常结果，但只有17例（18%）在所有三项检测中均正常。对这些患者的免疫复合物结果和广泛的临床和实验室数据进行的计算机辅助分析显示，Raji细胞检测结果异常的患者比Raji细胞检测结果阴性的患者更常患有弥漫性硬皮病、肌腱摩擦和血清抗核抗体检测阳性。与C1q结合检测到的免疫复合物的个人有证据表明，肺部受累和阳性血清类风湿因子更频繁比患者的C1q测试是阴性的。
Serum immune complexes were measured in 92 patients with progressive systemic sclerosis, and elevated levels were found as follows: Raji cell assay 72% (59% after pronase treatment of Raji cells), agarose gel electrophoresis 52%, and C1q binding 24%. Fortythree (47%) had abnormal results on two or more of these tests, but only 17 (18%) had normal results by all three assays. Computer‐assisted analysis of immune complex results and extensive clinical and laboratory data compiled on these patients revealed that the patients with abnormal Raji cell assays more often had diffuse scleroderma, tendon friction rubs, and positive serum antinuclear antibody tests than did patients with negative results on Raji cell assays. Individuals with immune complexes detected by C1q binding had evidence of pulmonary involvement and positive serum rheumatoid factor more frequently than did patients whose C1q tests were negative.