Tales of Tails (and Trunks): Forming the Posterior Body in Vertebrate Embryos.
Tales of Tails (and Trunks): Forming the Posterior Body in Vertebrate Embryos.
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DOI：
10.1016/bs.ctdb.2015.12.008
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发表时间：
2016
影响因子：
--
通讯作者：
Kimelman D
中科院分区：
文献类型：
--
作者：
Kimelman D
发育生物学中的一个主要问题是早期胚胎轴是如何建立的。最近使用不同的模式生物和哺乳动物体外系统的研究揭示了令人惊讶的结果，即大多数早期后胚胎体从Wnt调节的双能神经中胚层祖细胞群体形成，其逃避早期胚层模式化。最近已经确定了驱动这些祖细胞维持和分化的调控网络的一部分，但仍有许多有待发现。这篇综述讨论了所有脊椎动物中存在的一些共同特征，以及不同物种用来建立前后（A-P）轴的独特方面。
A major question in developmental biology is how the early embryonic axes are established. Recent studies using different model organisms and mammalian in vitro systems have revealed the surprising result that most of the early posterior embryonic body forms from a Wnt regulated bipotential neuromesodermal progenitor population that escapes early germ layer patterning. Part of the regulatory network that drives the maintenance and differentiation of these progenitors has recently been determined, but much remains to be discovered. This review discusses some of the common features present in all vertebrates, as well as unique aspects that different species utilize to establish their anterior-posterior (A-P) axis.