Similarity of unitary Ca2+ currents in three different species.
Similarity of unitary Ca2+ currents in three different species.
复制标题
三个不同物种中单一 Ca2 电流的相似性。
作者：
Brown,AM;Camerer,H;Kunze,DL;Lux,HD
膜 Ca2+ 电流是许多细胞活动的触发因素，例如分泌、收缩和神经放电振荡。假设不同的 Ca2+ 通道有不同的功能1；这不适用于Na+电流，因为Na+电流被认为只有一种类型的通道。我们使用膜片钳方法检查了来自三个截然不同的物种（鸟、蜗牛和大鼠）的细胞中的单个 Ca2+ 通道，并在此报告单一事件由小而短暂的电流脉冲组成，这些脉冲通常以突发形式发生，并且对于所有三个物种来说都是相似的。因此，所报道的各种 Ca2+ 电流之间的差异必定有其他来源。
Membrane Ca2+currents are the triggers for numerous cellular activities such as secretion, contraction, and oscillations in neural discharge. Different Ca2+channels are assumed to subserve the various functions1; this does not apply to Na+currents for which there is thought to be only one type of channel. We have examined single Ca2+channels in cells from three very different species (bird, snail and rat) using the patch-clamp method2, and report here that unitary events consisted of small, brief current pulses that often occurred in bursts and were similar for all three species. Thus, reported differences among various Ca2+currents1must have other origins.