The Genetics of Eating Disorders
The Genetics of Eating Disorders
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DOI：
10.1146/annurev-clinpsy-050212-185546
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Bulik, Cynthia M.
中科院分区：
文献类型：
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作者：
Trace, Sara E.;Baker, Jessica H.;Bulik, Cynthia M.
在过去的十年中，在理解遗传对饮食病理学的影响方面取得了相当大的进展。饮食失调在家庭中聚集，双胞胎研究表明，加性遗传因素约占神经性厌食症（AN），神经性贪食症（BN）和暴食症（BED）的40%至60%。已开展分子遗传学研究，以确定可能参与饮食行为障碍、症状和相关疾病发病机制的脱氧核糖核酸序列和/或基因表达的改变，并发现可能导致治疗反应变异性的潜在遗传变异。本文对AN、BN和BED遗传学的科学文献进行了深入的综述，包括现有研究、新兴假设、未来方向和临床意义。
Over the past decade, considerable advances have been made in understanding genetic influences on eating pathology. Eating disorders aggregate in families, and twin studies reveal that additive genetic factors account for approximately 40% to 60% of liability to anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Molecular genetics studies have been undertaken to identify alterations in deoxyribonucleic acid sequence and/or gene expression that may be involved in the pathogenesis of disordered eating behaviors, symptoms, and related disorders and to uncover potential genetic variants that may contribute to variability of treatment response. This article provides an in-depth review of the scientific literature on the genetics of AN, BN, and BED including extant studies, emerging hypotheses, future directions, and clinical implications.