Interneurons are the source and the targets of the first synapses formed in the rat developing hippocampal circuit
Interneurons are the source and the targets of the first synapses formed in the rat developing hippocampal circuit
复制标题
DOI：
10.1093/cercor/13.6.684
复制
发表时间：
2003-06-01
期刊：
影响因子：
3.7
通讯作者：
Ben-Ari, Y
中科院分区：
文献类型：
--
作者：
Gozlan, H;Ben-Ari, Y
在海马CA1区锥体神经元中，GABA能突触先于谷氨酸能突触建立。因此，GABA能中间神经元应该在早期发育和获得突触，以提供GABA能突触的来源。我们现在报告，情况确实如此。在出生和子宫内时，几乎所有的锥体神经元都还没有功能，大多数中间神经元已经只有GABA能或GABA能和多巴胺能突触后电流。在出生时，中间神经元的形态成熟与其个体功能反应平行。此外，功能性中间神经元类型的形成似乎是一个连续的过程。支配其他中间神经元的中间神经元在胞体周围中间神经元之前获得GABA（A）突触，但也在出生时尚未发挥功能的体周中间神经元之前获得GABA（A）突触。因此，中间神经元是在发育回路中形成的第一突触的来源和目标。由于GABA在子宫内被证明是兴奋性的，所以当主细胞沉默时，中间神经元提供所有的兴奋性驱动。因此，它们可以在早期发育阶段的皮层回路的形成中发挥核心作用。
In hippocampal CA1 pyramidal neurons, GABAergic synapses are established before glutamatergic synapses. GABAergic interneurons should therefore develop and acquire synapses at an earlier stage to provide the source for GABAergic synapses. We now report that this is indeed the case. At birth and in utero, when nearly all pyramidal neurons are not yet functional, most interneurons have already either GABAergic only or GABAergic and glutamatergic postsynaptic currents. At birth, the morphological maturation of interneurons parallels their individual functional responses. In addition, the formation of functional interneurons types appears to be a sequential process. Interneurons that innervate other interneurons acquire GABA(A) synapses before peridendritic interneurons, but also before perisomatic interneurons that are not yet functional at birth. Therefore, interneurons are the source and the targets of the first synapses formed in the developing circuit. Since GABA was shown to be excitatory in utero, interneurons provide all the excitatory drive at a time when the principal cells are silent. They could therefore play a central role in the formation of the cortical circuit at early developmental stages.