Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila.
Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila.
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发表时间：
1998-10
期刊：
影响因子：
4.6
通讯作者：
T. Haerry;Ongkar Khalsa;M. O’Connor;K. Wharton
中科院分区：
文献类型：
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作者：
T. Haerry;Ongkar Khalsa;M. O’Connor;K. Wharton
在果蝇翅盘，形态梯度的DPP已被提出来确定下游基因sal和omb的转录反应阈值。我们提出的证据表明，I型受体TKV的浓度必须低，以允许长距离DPP扩散。然而，低TKV受体浓度导致低信号传导活性。为了在低DPP浓度下增强信号传导，我们发现第二种配体GBB增强DPP/TKV活性。GBB主要通过I型受体SAX进行信号传导，其协同增强TKV信号传导并且是适当OMB表达所需的。我们表明，OMB在翼盘中的表达需要多个配体和受体的协同信号传导，以克服由受体浓度水平对DPP形态原功能施加的限制。
In Drosophila wing discs, a morphogen gradient of DPP has been proposed to determine the transcriptional response thresholds of the downstream genes sal and omb. We present evidence that the concentration of the type I receptor TKV must be low to allow long-range DPP diffusion. Low TKV receptor concentrations result, however, in low signaling activity. To enhance signaling at low DPP concentrations, we find that a second ligand, GBB, augments DPP/TKV activity. GBB signals primarily through the type I receptor SAX, which synergistically enhances TKV signaling and is required for proper OMB expression. We show that OMB expression in wing discs requires synergistic signaling by multiple ligands and receptors to overcome the limitations imposed on DPP morphogen function by receptor concentration levels.