IL-6, TNF-α and atherosclerosis risk indicators in a healthy family population:: the STANISLAS cohort
IL-6, TNF-α and atherosclerosis risk indicators in a healthy family population:: the STANISLAS cohort
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DOI：
10.1016/s0021-9150(03)00287-9
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发表时间：
2003-10-01
期刊：
影响因子：
5.3
通讯作者：
Visvikis, S
中科院分区：
文献类型：
--
作者：
Haddy, N;Sass, C;Visvikis, S
在大量健康年轻人群中，关于炎性细胞因子的循环浓度及其与传统和非传统动脉粥样硬化危险因素的潜在关系还没有令人满意的数据。本研究在从STANISLAS队列中选择的179个健康家庭中进行，以检查白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C-反应蛋白（CRP）、血清类粘蛋白、触珠蛋白、细胞粘附分子（ICAM- 1、E-、L-和P-选择素）和脂质参数浓度之间的关联。年龄、体重指数、白色血细胞和吸烟对IL-6浓度的变化有影响。年龄和烟草也有助于TNF-α的变化。考虑到潜在的协变量，我们发现IL-6与炎症标志物TNF-α和CRP在父母和后代中呈强正相关（P < 0.00 1）。在亲代中，IL-6与ICAM-1和L-选择素相关（P <0.01），而在子代中，IL-6和TNF-α仅预测E-选择素（0.001 < P <0.01）。IL-6与apoA-I、HDL-胆固醇呈显著负相关（P <0.001）。这项研究表明，在一个大型的健康家庭人口，包括儿童，IL-6水平与传统和非传统的动脉粥样硬化危险因素密切相关。所有这些数据都有助于确定细胞因子在生理条件下动脉粥样硬化机制中的确切作用。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
There are no satisfactory data on circulating concentrations of inflammatory cytokines and their potential relationship with traditional and nontraditional atherosclerosis risk factors in a large healthy young Population. The present Study was conducted to examine, in 179 healthy families selected from the STANISLAS cohort, the association between interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), orosomucoid, haptoglobin, cell-adhesion molecules (ICAM- 1, E-, L- and P-selectin) and lipid parameter concentrations. Age, BMI, white blood cells and tobacco consumption contributed to the variation of IL-6 concentrations. Age and tobacco contributed also to TNF-alpha variation. Taking into account potential covariates, we showed strong positive correlation between IL-6 and both inflammatory markers TNF-alpha and CRP in parents and in offspring (P < 0.00 1). In parents, IL-6 was associated with ICAM- I and L-selectin (P < 0.0 1), while IL-6 and TNF-alpha predicted E-selectin in offspring only (0.00 1 < P < 0.0 1). Furthermore, IL-6 showed a strong negative relationship with apo A- I and HDL-cholesterol in females only (P < 0.00 1). This study demonstrated that in a large healthy family population, children included, levels of IL-6 are closely associated with traditional and non-traditional atherosclerosis risk factors. All these data are useful for defining the precise role of cytokines in atherosclerosis mechanisms in physiological conditions. (C) 2003 Elsevier Ireland Ltd. All rights reserved.