Fatigue associated with cancer and its treatment
Fatigue associated with cancer and its treatment
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DOI：
10.1007/s005200100293
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发表时间：
2002-07-01
影响因子：
3.1
通讯作者：
Matteson, S
中科院分区：
文献类型：
--
作者：
Morrow, GR;Andrews, PLR;Matteson, S
疲劳通常与癌症有关，与其治疗有关的是癌症治疗最常见的副作用。它不同于由其他原因引起的，如睡眠障碍和劳累，因为后者通常通过休息一段时间来缓解。与运动引起的疲劳相反，癌症患者报告的疲劳通常被描述为一种不寻常的、过度的、全身的体验，与活动或劳累不成比例或无关，并且不能通过休息或睡眠来缓解。癌症相关疲劳是一种主观体验，对癌症患者的生活质量和维持通常的个人，职业和社会关系的能力有明显的不利影响。疲劳可能是普遍的：癌症患者经常报告疲劳从治疗开始，在化疗或放射治疗过程中持续，并且在治疗结束后稍微下降，但经常维持在高于基线的速率。它也可能持续数年，甚至在没有明显疾病的患者中。虽然许多研究人员已经推测了癌症相关疲劳的性质，但对其病因或治疗的系统研究很少。在许多方面，我们对癌症患者疲劳机制的认识与大约20年前我们对抗癌治疗引起的恶心和呕吐的认识处于相似的阶段。本文介绍了疲劳发展的四种可能的假说。证据支持贫血，三磷酸腺苷，迷走神经传入，HPA/细胞因子和5 HT的相互作用的作用进行了讨论。
Fatigue is often related to cancer, and that related to its treatment is the most commonly reported side effect of cancer treatment. It differs from that induced by other causes, such as sleep disturbance and exertion, as the latter are typically alleviated by a period of rest. In contrast to exercise-induced fatigue, the fatigue reported by cancer patients is usually described as an unusual, excessive, whole-body experience that is disproportionate or unrelated to activity or exertion and is not relieved by rest or sleep. Cancer-related fatigue is a subjective experience that has a clear detrimental effect on a cancer patient's quality of life and ability to sustain the usual personal, professional, and social relationships. The fatigue can be pervasive: cancer patients frequently report that fatigue begins with treatment, continues during the course of chemotherapy or radiation treatment, and declines somewhat - but frequently sustains at a higher-than-baseline rate - after treatment is over. It may also persist for several years even in patients with no apparent disease. While a number of researchers have speculated about the nature of cancer-related fatigue, there has been little systematic research on its etiology or treatment. In many aspects our knowledge of the fatigue mechanisms in cancer patients is at a similar stage to that reached in our understanding of anti-cancer therapy-induced nausea and vomiting about 20 years ago. This paper introduces four plausible hypotheses for the development of fatigue. Evidence available to support a role for anemia, adenosine triphosphate, vagal afferents, and the interaction of the HPA/cytokines and 5HT is discussed.