Neural dynamics in parkinsonian brain: the boundary between synchronized and nonsynchronized dynamics.
Neural dynamics in parkinsonian brain: the boundary between synchronized and nonsynchronized dynamics.
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帕金森氏脑中的神经动力学：同步和非同步动力学之间的边界。
DOI：
10.1103/physreve.83.042901
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Rubchinsky LL
中科院分区：
文献类型：
--
作者：
Park C;Worth RM;Rubchinsky LL
Synchronous oscillatory dynamics is frequently observed in the human brain. We analyze the fine temporal structure of phase-locking in a realistic network model and match it with the experimental data from parkinsonian patients. We show that the experimentally observed intermittent synchrony can be generated just by moderately increased coupling strength in the basal ganglia circuits due to the lack of dopamine. Comparison of the experimental and modeling data suggest that brain activity in Parkinson’s disease resides in the large boundary region between synchronized and nonsynchronized dynamics. Being on the edge of synchrony may allow for easy formation of transient neuronal assemblies.
