Genomic diversity and versatility of Lactobacillus plantarum, a natural metabolic engineer.
Genomic diversity and versatility of Lactobacillus plantarum, a natural metabolic engineer.
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DOI：
10.1186/1475-2859-10-s1-s3
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发表时间：
2011-08-30
影响因子：
6.4
通讯作者：
van Hylckama Vlieg JE
中科院分区：
文献类型：
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作者：
Siezen RJ;van Hylckama Vlieg JE
在过去的十年中，已经清楚的是，乳酸菌植物乳杆菌占据了各种各样的环境小生境，并在表型特性、代谢能力和工业应用方面具有巨大的多样性。在这篇综述中，我们描述了如何基因组测序，比较基因组杂交和比较基因组学提供了深入了解潜在的基因组多样性和通用性的L。植物主要特征之一似乎是由许多功能性基因盒组成的基因组生活方式岛，特别是用于碳水化合物利用，其可以响应于生态位需求而被获取、改组、取代或删除。在这个意义上，L。plantarum可以被认为是“天然代谢工程师”。
In the past decade it has become clear that the lactic acid bacterium Lactobacillus plantarum occupies a diverse range of environmental niches and has an enormous diversity in phenotypic properties, metabolic capacity and industrial applications. In this review, we describe how genome sequencing, comparative genome hybridization and comparative genomics has provided insight into the underlying genomic diversity and versatility of L. plantarum. One of the main features appears to be genomic life-style islands consisting of numerous functional gene cassettes, in particular for carbohydrates utilization, which can be acquired, shuffled, substituted or deleted in response to niche requirements. In this sense, L. plantarum can be considered a “natural metabolic engineer”.