Goal-directed behavior in individuals with mild Parkinson's disease: Role of self-efficacy and self-regulation.
Goal-directed behavior in individuals with mild Parkinson's disease: Role of self-efficacy and self-regulation.
复制标题
轻度帕金森病患者的目标导向行为：自我效能和自我调节的作用。
DOI：
10.1016/j.prdoa.2020.100051
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Sinha,Rajita
中科院分区：
文献类型：
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作者：
Tinaz,Sule;Elfil,Mohamed;Kamel,Serageldin;Aravala,SaiS;Louis,ElanD;Sinha,Rajita
目标导向行为的缺陷在帕金森病患者中很常见，并被归因于冷漠。除了冷漠之外，个体对自己能力（自我效能）和调节情绪、思想和行动（自我调节）的能力的信念也是目标导向行为的关键技能。我们调查了这些技能及其与PD患者运动和非运动症状的关系。我们还研究了这些技能的神经相关使用功能磁共振成像（fMRI）MethodsWe招募了35名轻度PD（Hoehn-Yahr阶段≤2.5），并使用新的一般自我效能（NGSES）和自我调节量表（SRS）。我们使用逐步回归分析将这些量表的得分与认知、焦虑、抑郁、冷漠、疲劳、生活质量和疾病负担的测量结果相关联。我们在一个3特斯拉的扫描仪中收集了静息状态的功能磁共振成像数据，并计算了主要网络节点之间的成对功能连接。我们相关的连接地图与NGSES和SRS scores.ResultsOur PD队列表现出完整的NGSES和SRS分数与各自的人口数据相比。这些得分与冷漠和疾病负担呈显著负相关。更强的连接性的显着性网络和解耦的默认模式网络支持自我效能和自我regulation.ConclusionsSelf-efficacy和自我调节能力似乎保存，但容易受到疾病相关因素的个人与轻度PD。培养这种能力的教育项目可以提高这些人的应对技能。功能连接的显着性和默认模式网络的变化可以作为神经生物学标记，以证明这种干预的有效性。
IntroductionDeficits in goal-directed behavior are common in individuals with Parkinson's disease (PD) and have been ascribed to apathy. In addition to apathy, individuals' beliefs in their competence (self-efficacy) and capacity to regulate emotions, thoughts, and actions (self-regulation) are critical skills for goal-directed behavior. We investigated these skills and their relationship to motor and non-motor symptoms in individuals with PD. We also examined the neural correlates of these skills using functional magnetic resonance imaging (fMRI).MethodsWe enrolled 35 subjects with mild PD (Hoehn and Yahr stage ≤2.5) and used the new general self-efficacy (NGSES) and self-regulation scales (SRS). We correlated the scores on these scales with measures of cognition, anxiety, depression, apathy, fatigue, quality of life, and disease burden using stepwise regression analyses. We collected resting-state fMRI data in a 3-Tesla scanner and computed the pairwise functional connectivity among nodes of major networks. We correlated the connectivity maps with the NGSES and SRS scores.ResultsOur PD cohort demonstrated intact NGSES and SRS scores compared with respective population data. These scores showed significant negative correlation with apathy and disease burden. Stronger connectivity in the salience network and decoupling from the default mode network supported self-efficacy and self-regulation.ConclusionsSelf-efficacy and self-regulation capacity seems preserved, but vulnerable to disease-related factors in individuals with mild PD. Educational programs cultivating this capacity could improve the coping skills of these individuals. Functional connectivity changes in salience and default mode networks may serve as neurobiological markers to demonstrate the effectiveness of such interventions.