Evidence for adult lung growth in humans.
Evidence for adult lung growth in humans.
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DOI：
10.1056/nejmoa1203983
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发表时间：
2012-07-19
期刊：
影响因子：
--
通讯作者：
Mentzer SJ
中科院分区：
文献类型：
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作者：
Butler JP;Loring SH;Patz S;Tsuda A;Yablonskiy DA;Mentzer SJ
一名33岁的女性在1995年接受了右侧肺切除术治疗肺腺癌。果然，她的肺活量突然下降，但没想到，在接下来的15年里，她的肺活量又增加了。连续计算机断层扫描（CT）显示剩余左肺进行性扩大和组织密度增加。使用超极化氦-3气体的磁共振成像（MRI）显示总体腺泡气道尺寸与肺泡数量增加而不是现有肺泡扩大一致，但生长中的肺中的肺泡比正常肺中的浅。这项研究提供了新的肺生长可以发生在成年人的证据。
A 33-year-old woman underwent a right-sided pneumonectomy in 1995 for treatment of a lung adenocarcinoma. As expected, there was an abrupt decrease in her vital capacity, but unexpectedly, it increased during the subsequent 15 years. Serial computed tomographic (CT) scans showed progressive enlargement of the remaining left lung and an increase in tissue density. Magnetic resonance imaging (MRI) with the use of hyperpolarized helium-3 gas showed overall acinar-airway dimensions that were consistent with an increase in the alveolar number rather than the enlargement of existing alveoli, but the alveoli in the growing lung were shallower than in normal lungs. This study provides evidence that new lung growth can occur in an adult human.