Stabilizing of Amyloid-β Peptide by the N-terminus Capture is Capable of Preventing and Eliminating Amyloid-β Oligomers
Stabilizing of Amyloid-β Peptide by the N-terminus Capture is Capable of Preventing and Eliminating Amyloid-β Oligomers
复制标题
通过 N 末端捕获稳定淀粉样蛋白-β 肽能够预防和消除淀粉样蛋白-β 寡聚体
DOI：
10.1039/c7cc03102e
复制
发表时间：
2017
影响因子：
4.9
通讯作者：
Xianzhang Bu
中科院分区：
文献类型：
--
作者：
Gesi Wen;Daoyuan Chen;Wenjing Qin;Binhua Zhou;Youqiao Wang;Ziyi Liu;Jun Du;Qiang Zhou;Junmin Quan;Xianzhang Bu
淀粉样蛋白-β (Aβ)低聚物的消除仍然具有挑战性。我们在这里描述了一种新的策略，通过合理设计的环肽，通过靶向柔性n端，而不是广泛研究的疏水段，来防止和消除a β低聚物的早期聚集或纤维溶解途径。
Elimination of amyloid-β (Aβ) oligomers remains challenging. We describe here a novel strategy to prevent and eliminate the Aβ oligomers from either the early aggregation or the fibril dissolution pathway by targeting the flexible N-terminus, but not the widely investigated hydrophobic segment, with a rationally designed cyclopeptide.