Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer
Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer
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DOI：
10.1056/nejm199908263410923
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发表时间：
1999
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影响因子：
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通讯作者：
K. Blank
中科院分区：
文献类型：
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作者：
K. Blank
介绍局部晚期宫颈癌妇女的治疗正在发展。放射治疗和化学治疗形成了美国的标准治疗;然而，最佳化疗类型是有争议的。传统上，羟基脲是与放射同时使用的药物;与单独放射治疗相比，它显著增加了获得完全缓解和延长总生存期的可能性。然而，I期和II期试验表明，顺铂，有或没有氟尿嘧啶，可能比羟基脲更有效。为了评估局部晚期宫颈癌的最佳化疗方案，妇科肿瘤组（GOG）开展了一项试验，将患者随机分为三种化疗方案之一，同时给予放疗。三个研究组为1）每周一次顺铂，2）顺铂、羟基脲和氟尿嘧啶，3）羟基脲。这项试验的结果发表在1999年4月15日的新英格兰医学杂志上。
Introduction The treatment of women with locally advanced cervical cancer is evolving. Radiotherapy and chemotherapy form the standard of care in the United States; however, the optimal type of chemotherapy is controversial. Traditionally, hydroxyurea has been the agent used concurrently with radiation; compared to radiotherapy alone, it significantly increases the likelihood of obtaining a complete response and prolongs overall survival. However, Phase I and II trials have indicated that cisplatin, with or without fluorouracil, may be more effective than hydroxyurea. To evaluate the optimal chemotherapy regimen for locally advanced cervical cancer, the Gynecologic Oncology Group (GOG) instituted a trial randomizing patients to one of three chemotherapy regimens given concurrently with radiotherapy. The three study arms were 1) weekly cisplatin 2) cisplatin, hydroxyurea and fluorouracil, 3) hydroxyurea. The results of this trial were reported in the April 15, 1999 issue of the New England Journal of Medicine.