Impairment of individual finger movements in Parkinson's disease
Impairment of individual finger movements in Parkinson's disease
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DOI：
10.1002/mds.10313
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发表时间：
2003-05-01
影响因子：
8.6
通讯作者：
Berardelli, A
中科院分区：
文献类型：
--
作者：
Agostino, R;Currà, A;Berardelli, A
通过分析重复、恒定幅度、手指对立的运动学，我们比较了帕金森病患者的个体和非个体手指运动的损伤。在一项任务中，受试者仅用食指敲击拇指（个人反对）；在另一项任务中，他们将所有四个手指一起敲击拇指垫（非个人对抗）。我们使用光电运动分析系统来记录三维空间中的运动，并为每个任务记录 3 个 5 秒的试验。我们计算了每次试验期间受试者进行的响铃对立次数，并测量了屈曲和伸展的持续时间和幅度。我们还计算了屈曲和伸展后暂停的持续时间。 61 我们通过调查任务完成过程中速度和幅度的变化来评估患者运动表现的恶化情况。在这两项任务中，正常受试者和患者的手指弯曲速度都快于伸展速度，并且他们在弯曲后的停顿时间总是比伸展后的停顿时间长。患者缓慢且幅度减小地进行个体和非个体手指运动。患者在屈曲和从屈曲转换为伸展时速度异常缓慢。随着手指对立的进展，运动速度变慢，但主要是当患者必须单独移动手指时。总之，在帕金森病患者中，与非个体手指运动相比，个体手指运动期间运动表现随着任务完成而恶化。因此，帕金森病对个人手指运动的影响比对整体手部运动的影响更大。这种区别反映了促进和维持这种高度分散类型的运动输出所需的更精细的皮质控制。 (C) 2003 年运动障碍协会。
By analyzing the kinematics of repetitive, constant-amplitude, finger oppositions, we compared the impairment of individual and nonindividual finger movements in patients with Parkinson's disease. In one task, subjects tapped only the index finger against the thumb (individual oppositions); in the other task, they tapped all four fingers together against the thumb pad (nonindividual oppositions). We used an optoelectronic motion analysis system to record movements in three-dimensional space and recorded three 5-second trials for each task. We counted how many ringer oppositions subjects performed during each trial and measured the duration and amplitude of the flexions and extensions. We also calculated the duration of the pauses after flexion and extension. 61 We assessed the deterioration of motor performance in patients by investigating the changes in speed and amplitude with task completion. During both tasks, normal subjects and patients performed finger flexions faster than extensions, and they invariably paused longer after flexion than after extension. Patients performed individual and nonindividual finger movements slowly and with reduced amplitude. Patients were disproportionately slow during flexion and in switching from flexion to extension. Movement slowness increased as finger oppositions progressed but predominantly when patients had to move fingers individually. In conclusion, in patients with Parkinson's disease, the motor performance deteriorated with task completion more during individual than during nonindividual finger movements. Parkinson's disease, therefore, impairs individual finger movements more than gross hand movements. This distinction reflects the finer cortical control needed to promote and sustain this highly fractionated type of motor output. (C) 2003 Movement Disorder Society.