Immunology of fungal infections: lessons learned from animal models.
Immunology of fungal infections: lessons learned from animal models.
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真菌感染的免疫学：从动物模型中吸取的教训。
DOI：
10.1016/j.mib.2012.05.017
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发表时间：
2012
影响因子：
5.4
通讯作者：
WormleyJr,FloydL
中科院分区：
文献类型：
--
作者：
Steele,Chad;WormleyJr,FloydL
持续的艾滋病流行加上增加使用免疫抑制药物来防止器官排斥或治疗自身免疫性疾病，导致个体获得真菌疾病的风险增加。这些问题突出了需要阐明机制诱导保护性免疫反应对真菌病原体。因此，已经开发了几种人类真菌病的实验模型来研究这些疾病。转基因动物模型的可用性允许深入分析引起对真菌疾病的保护的特定组分、受体和信号通路。本文综述了近年来在真菌感染动物模型免疫反应的研究进展。
The continuing AIDS epidemic coupled with increased usage of immunosuppressive drugs to prevent organ rejection or treat autoimmune diseases has resulted in an increase in individuals at risk for acquiring fungal diseases. These concerns highlight the need to elucidate mechanisms of inducing protective immune responses against fungal pathogens. Consequently, several experimental models of human mycoses have been developed to study these diseases. The availability of transgenic animal models allows for in-depth analysis of specific components, receptors, and signaling pathways that elicit protection against fungal diseases. This review focuses on recent advances in our understanding of immune responses to fungal infections gained using animal models.