Polycyclic aromatic hydrocarbon oxidation during prostaglandin biosynthesis.
Polycyclic aromatic hydrocarbon oxidation during prostaglandin biosynthesis.
复制标题
前列腺素生物合成过程中的多环芳烃氧化。
DOI：
10.1016/0024-3205(81)90431-8
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发表时间：
1981
期刊：
影响因子：
6.1
通讯作者：
Marnett,LJ
中科院分区：
文献类型：
--
作者：
Marnett,LJ
在多不饱和脂肪酸的氧化代谢过程中，多环烃和其他异生物质被共氧化。多环烃共氧化的产物取决于烃，但它们似乎是通过自由基（或电子转移）机制形成的。共氧化是由过氧化物酶催化的氢过氧化物依赖性氧化，并且可以由生物合成脂肪酸氢过氧化物的酶触发。前列腺素内过氧化物合成酶是迄今为止已被研究的主要过氧化氢生成系统。多不饱和脂肪酸依赖性共氧作用在体内的作用程度尚不确定，但初步研究表明它确实存在。
Polycyclic hydrocarbons and other xenobiotics are cooxygenated during the oxidative metabolism of polyunsaturated fatty acids. The products of polycyclic hydrocarbon cooxygenation depend upon the hydrocarbon but they appear to be formed by radical (or electron transfer) mechanisms. The cooxygenations are hydroperoxide-dependent oxidations catalyzed by peroxidases and may be triggered by enzymes which biosynthesize fatty acid hydroperoxides. Prostaglandin endoperoxide synthetase is the principal hydroperoxide-generating system which has been studied to date. The extent to which polyunsaturated fatty acid-dependent cooxygenation operates in vivo is uncertain but preliminary studies suggest it does occur.