Genetic approaches to the study of Toll-like receptor function
Genetic approaches to the study of Toll-like receptor function
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DOI：
10.1016/s1286-4579(02)01615-5
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发表时间：
2002-07-01
影响因子：
5.8
通讯作者：
Akira, S
中科院分区：
文献类型：
--
作者：
Takeuchi, O;Akira, S
Toll样受体（TLR）家族在感知入侵病原体中起作用。到目前为止，已经报道了10个成员，其中7个被发现识别离散的细菌成分。缺乏每种TLR及其信号分子的小鼠模型是用于分析先天免疫系统的有用工具。(C)2002年，Elsevier SAS科学与医学版。All rights reserved.
The Toll-like receptor (TLR) family plays a role in sensing invading pathogens. Ten members have been reported to date, seven of which were found to recognize discrete bacterial components. Mouse models lacking each TLR and its signaling molecule are useful tools for the analysis of the innate immune system. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.