INCIDENCE OF SUBACUTE SCLEROSING PANENCEPHALITIS FOLLOWING MEASLES AND MEASLES VACCINATION IN JAPAN
INCIDENCE OF SUBACUTE SCLEROSING PANENCEPHALITIS FOLLOWING MEASLES AND MEASLES VACCINATION IN JAPAN
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DOI：
10.1093/ije/18.3.684
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发表时间：
1989-09-01
影响因子：
7.7
通讯作者：
KAJI, M
中科院分区：
文献类型：
--
作者：
OKUNO, Y;NAKAO, T;KAJI, M
日本国家亚急性硬化性全脑炎（SSPE）登记委员会证实，在1976年4月至1986年3月的10年监测中发现，从1966年至1985年的20年间发生了215例SSPE。近年来的年发病率在10至23例之间。在有一定麻疹病史或麻疹疫苗接种史的病例中，有麻疹病史但未接种麻疹疫苗者184例（90.2%）。有11例可能与麻疹疫苗有关的病例（5.4%），3例（1.5%）接种了灭活疫苗和活疫苗的联合使用，8例（3.9%）接种了进一步减毒活疫苗。有9例（4.4%）没有麻疹病史或麻疹疫苗接种史。麻疹发病与SSPE发病之间的间隔时间为1 ~ 16年（平均7.0年）。麻疹减毒活疫苗接种后2 ~ 11年（平均4.6年）。在1968-1977年的10个麻疹流行年中，每100万例麻疹病例中SSPE的年发病率为6.1 ~ 40.9（平均16.1），接种减毒活疫苗后的年发病率大多为0，最高为3.08（平均0.9）/100万剂次。
The Japanese Committee for the National Registry of Subacute Sclerosing Panencephalitis (SSPE) confirmed that 215 cases of SSPE occurred in the 20 years from 1966 to 1985, as discovered in the 10-year surveillance from April 1976 through March 1986. The annual incidence in recent years has been between 10 and 23 cases. Among cases with a certain history of measles or measles illness vaccination, 184 (90.2%) had a history of measles illness without receiving measles vaccine. There were 11 probable measles vaccine-associated cases (5.4%), three (1.5%) being vaccinated with a combined use of killed and live vccine and eight (3.9%) with further attenuated live vaccine. There were nine cases (4.4%) without a history of either measles illness or measles vaccination. Intervals between measles illness and the onset of SSPE varied from 1 to 16 years (mean, 7.0 years). The periods following measles vaccination with further attenuated live vaccine were 2 to 11 years (mean, 4.6 years). Annual incidence rates of SSPE per million cases of measles ranged between 6.1 and 40.9 (mean, 16.1) in the 10 measles epidemic years 1968-1977, and those following vaccination with further attenuated live vaccine were zero in most years and at the highest 3.08 (mean, 0.9) per million doses of distributed vaccine.