Roles of the multifunctional glycoprotein, emmprin (basigin; CD 147), in tumour progression
Roles of the multifunctional glycoprotein, emmprin (basigin; CD 147), in tumour progression
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DOI：
10.1160/th04-08-0536
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发表时间：
2005-02-01
影响因子：
6.7
通讯作者：
Toole, BR
中科院分区：
文献类型：
--
作者：
Yan, L;Zucker, S;Toole, BR
埃姆普林（basigin; CD 147）是一种广泛分布的细胞表面糖蛋白，属于IG超家族，并高度富集在恶性肿瘤细胞表面。细胞外基质金属蛋白酶诱导因子参与许多生理和病理系统，并表现出多种分子和细胞特征，但其主要功能是刺激多种基质金属蛋白酶的合成。在肿瘤中，emmprin最有可能刺激基质成纤维细胞和内皮细胞以及肿瘤细胞本身的基质金属蛋白酶的产生，其机制涉及膜囊泡脱落后的贴壁细胞或相邻细胞上的emmprin分子之间的亲嗜性相互作用。膜相关的辅因子，包括小窝蛋白-I和膜联蛋白II，调节emmprin活性。细胞外基质金属蛋白酶诱导血管生成通过刺激血管内皮生长因子的产生，通过刺激基质金属蛋白酶的产生和多药耐药性通过透明质酸介导的ErbB 2信号和细胞存活途径活性的上调的侵袭性。虽然它调节这些众多现象的详细机制尚不清楚，但很明显，emmprin是恶性细胞行为的主要介质。
Emmprin (basigin;CD 147) is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of malignant tumour cells. Emmprin is involved in numerous physiological and pathological systems and exhibits several molecular and cellular characteristics, but a major function of emmprin is stimulation of synthesis of several matrix metalloproteinases. In tumours, emmprin most likely stimulates matrix metalloproteinase production in stromal fibroblasts and endothelial cells as well as in tumour cells themselves by a mechanism involving homophilic interactions between emmprin molecules on apposing cells or on neighbouring cells after membrane vesicle shedding. Membrane-associated cofactors, including caveolin-I and annexin II, regulate emmprin activity. Emmprin induces angiogenesis via stimulation of VEGF production, invasiveness via stimulation of matrix metalloproteinase production and multidrug resistance via hyaluronan-mediated up-regulation of ErbB2 signaling and cell survival pathway activities. Although the detailed mechanisms whereby it regulates these numerous phenomena are not yet known, it is clear that emmprin is a major mediator of malignant cell behavior.