Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes.
Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes.
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暴发性心肌炎：从病因到治疗和结果的全面回顾
DOI：
10.1038/s41392-020-00360-y
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发表时间：
2020-12-11
影响因子：
39.3
通讯作者：
Wang DW
中科院分区：
文献类型：
--
作者：
Hang W;Chen C;Seubert JM;Wang DW
暴发性心肌炎（FM）的特点是心脏功能迅速进行性下降和高死亡率。自20世纪80年代首次报道FM患者以来，已经发表了几项临床试验和研究，增加了我们对FM的了解。目前，FM的诊断依赖于各种技术，包括心电图、超声心动图、肌内膜活检和心脏磁共振。随着机械循环支持（MCS）设备的发展以及我们对FM病理生理机制的理解的进展，治疗方案已从简单的对症治疗发展到基于生命支持的综合治疗方法。FM发展的核心机制是炎症细胞因子风暴的发生。这篇综述提供了一个全面的帐户，目前了解FM的病理生理学和知识，其病因，病理生理学，治疗和结果。
Fulminant myocarditis (FM) is characterized by a rapid progressive decline in cardiac function and a high mortality rate. Since the first report of FM patients in the 1980s, several clinical trials and research studies have been published increasing our knowledge regarding FM. Currently, the diagnosis of FM depends on various techniques including electrocardiography, echocardiography, endomyocardial biopsy, and cardiac magnetic resonance. The development of mechanical circulation support (MCS) devices and progress in our understanding of the pathophysiological mechanisms underlying FM, treatment regimens have evolved from simple symptomatic treatment to a life support-based comprehensive treatment approach. The core mechanism underlying the development of FM is the occurrence of an inflammatory cytokine storm. This review provides a comprehensive account of the current understanding of FM pathophysiology and knowledge regarding its etiology, pathophysiology, treatments, and outcomes.
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影响因子：
37.8
作者：
Casella, Michela;Dello Russo, Antonio;Tondo, Claudio
通讯作者：
Tondo, Claudio
影响因子：
4.2
作者：
Chaparro, Sandra V.;Badheka, Apurva;Pham, Si M.
通讯作者：
Pham, Si M.
DOI：
10.1016/j.trsl.2017.10.012
发表时间：
2018-05
期刊：
Translational research : the journal of laboratory and clinical medicine
影响因子：
--
作者：
Abdullah M;Berthiaume JM;Willis MS
通讯作者：
Willis MS
影响因子：
--
作者：
Bracamonte-Baran W;Čiháková D
通讯作者：
Čiháková D
影响因子：
3.7
作者：
Blagova, Olga;Nedostup, Alexander;Fomin, Victor
通讯作者：
Fomin, Victor