Differentiation between recurrent gliomas and radiation necrosis using arterial spin labeling perfusion imaging
Differentiation between recurrent gliomas and radiation necrosis using arterial spin labeling perfusion imaging
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使用动脉自旋标记灌注成像区分复发性胶质瘤和放射性坏死
DOI：
10.3892/etm.2016.3225
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发表时间：
2016-06-01
影响因子：
2.7
通讯作者：
Yang, Guomei
中科院分区：
文献类型：
--
作者：
Ye, Jing;Bhagat, Santosh Kumar;Yang, Guomei
动脉自旋标记（ASL）磁共振（MR）灌注成像已被提出作为一种有效的方法来测量脑肿瘤灌注。本研究的目的是评估该技术在区分复发性胶质瘤和放射性坏死方面的实用性。本文对21例经手术治疗的原发性胶质瘤进行了3.0T磁共振成像（MRI）检查，其中复发性胶质瘤16例，放射性坏死5例。进行ASL和动态磁敏感对比加权（DSC）灌注MRI扫描。计算并分析感兴趣区ASL成像的标准化脑血流量（CBF）图和DSC成像的脑血容量（CBV）图。胶质瘤复发组ASL-CBF比值（4.45 ± 2.72）高于放射损伤组（1.22 ± 0.61）（P
Arterial spin labeling (ASL) magnetic resonance (MR) perfusion imaging has been proposed as an effective method to measure brain tumor perfusion. The aim of the present study was to evaluate the utility of this technique in the differentiation of recurrent gliomas from radiation necrosis. Twenty-one patients with surgically treated primary gliomas, including 16 cases of recurrent glioma and 5 of radiation necrosis were examined using 3.0T MR imaging (MRI). ASL and dynamic susceptibility contrast-weighted (DSC) perfusion MRI scans were performed. Maps of normalized cerebral blood flow (CBF) in ASL imaging and cerebral blood volume (CBV) in DSC imaging were computed and analyzed in the regions of interest. In cases of glioma recurrence, the normalized ASL-CBF ratio (4.45 +/- 2.72) was higher than that in cases of radiation injury (1.22 +/- 0.61) (P