Hepatoblastoma in a girl with biliary atresia: Coincidence or co‐incidence
Hepatoblastoma in a girl with biliary atresia: Coincidence or co‐incidence
复制标题
胆道闭锁女孩的肝母细胞瘤：巧合还是巧合
DOI：
10.1002/pbc.20115
复制
发表时间：
2004
影响因子：
3.2
通讯作者：
D. Aronson
中科院分区：
文献类型：
--
作者：
F. Taat;D. Bosman;D. Aronson
肝母细胞瘤（HB）和胆道闭锁（BA）都是罕见的情况发生在病人描述。这是文献中第二个这样的案例。这种明显的巧合或许可以从多能性肝干细胞的存在中找到解释。在人类中，小上皮细胞（SEC）表现为多能干细胞。这些细胞可以发育为胆道上皮细胞或肝实质细胞，被认为是HB的前体细胞。它们在BA患者的肝脏中以高得多的浓度存在，这可能使他们容易发展为HB。©2004 Wiley‐Liss, Inc。
Hepatoblastoma (HB) and biliary atresia (BA) are both rare conditions that occurred in the patient described. This is the second such case in the literature. An explanation for this apparent coincidence could possibly be found in the existance of pluripotent liver stem cells. In humans, small epithelial cells (SEC) behave as pluripotent stem cells. These are cells that can develop as biliary epithelial cells or as liver parenchymal cells, and are thought to be the precursor cell of HB. They are present in a much higher concentration in the livers of patients with BA, which may make them prone to develop HB. © 2004 Wiley‐Liss, Inc.