Tolerance and near‐tolerance strategies in monkeys and their application to human renal transplantation
Tolerance and near‐tolerance strategies in monkeys and their application to human renal transplantation
复制标题
猴子的耐受和近耐受策略及其在人肾移植中的应用
DOI：
10.1034/j.1600-065x.2001.1830116.x
复制
发表时间：
2001
影响因子：
8.7
通讯作者：
C. Cho
中科院分区：
文献类型：
--
作者：
S. Knechtle;M. Hamawy;Huaizhong Hu;John H. Fechner, Jr.;C. Cho
摘要：在非人类灵长类动物中评估器官移植耐受策略的研究导致了人类移植的创新。我们在非人灵长类动物中详细研究了两种策略：抗CD3免疫毒素消耗T细胞和共刺激阻断。这些策略中的每一个都已扩展到肾移植的早期人体试验中。本文对人类和非人类灵长类动物的研究结果进行了总结。在更好和更安全的免疫抑制方法方面的持续进展与非人灵长类动物的研究密切相关。然而，灵长类动物的疗效与人类的疗效之间并没有一对一的对应关系。相反，原理可以从非人类灵长类动物的研究中得到，并可以扩展到人类试验中，因为我们知道，与非人类灵长类动物相比，人类的治疗方案可能会有所不同。
Summary: Studies in non‐human primates to evaluate tolerance strategies in organ transplantation have led to innovation in human transplantation. The two strategies we have studied in detail in non‐human primates are T‐cell depletion by anti‐CD3 immunotoxin and co‐stimulation blockade. Each of these strategies has been extended into early human trials in renal transplantation. The results of these human and non‐human primate studies are summarized. Continued progress in better and safer immunosuppressive methods remains closely linked to research using non‐human primates. However, there has not been a one‐to‐one correspondence between efficacy in the primate and efficacy in humans. Rather, principles can be derived from non‐human primate studies that can be extended into human trials with the knowledge that regimens will likely differ in humans compared to non‐human primates.